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10.1523/JNEUROSCI.20-21-j0002.2000 http://scihub22266oqcxt.onion/10.1523/JNEUROSCI.20-21-j0002.2000 11050146!6772732!11050146     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurosci 2000 ; 20 (21): RC104 Nephropedia Template TP {{tp|p=11050146|t=2000. Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability |pdf=|usr=}}{{11050146}} gab.com Text Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability JO: J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=11050146 #FOAvip Hypothesized risk factors for psychostimulant, amphetamine, and cocaine abuse include dopamine (DA) receptor polymorphisms, HIV infection, schizophrenia, drug-induced paranoias, and movement disorders; however, the molecular, cellular, and biochemical mechanisms that predispose to drug sensitivity or drive the development of addiction are incompletely understood. Using the Borna disease rat, an animal model of viral-induced encephalopathy wherein sensitivity to the locomotor and stereotypic behavioral effects of d-amphetamine and cocaine is enhanced (Solbrig et al., 1994, 1998), we identify a specific neurotrophin expression pattern triggered by striatal viral injury that increases tyrosine hydroxylase activity, an early step in DA synthesis, to produce a phenotype of enhanced amphetamine sensitivity. The reactive neurotrophin pattern provides a molecular framework for understanding how CNS viral injury, as well as other CNS adaptations producing similar growth factor activation profiles, may influence psychostimulant sensitivity. Twit Text FOAVip Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability ????J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=11050146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=11050146 #FOAvip English Wikipedia <ref>{{Cite pmid|11050146}}</ref> Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability #MMPMID11050146 Solbrig MV; Koob GF; Parsons LH; Kadota T; Horscroft N; Briese T; Lipkin WI J Neurosci 2000[Nov]; 20 (21): RC104 PMID11050146show ga Hypothesized risk factors for psychostimulant, amphetamine, and cocaine abuse include dopamine (DA) receptor polymorphisms, HIV infection, schizophrenia, drug-induced paranoias, and movement disorders; however, the molecular, cellular, and biochemical mechanisms that predispose to drug sensitivity or drive the development of addiction are incompletely understood. Using the Borna disease rat, an animal model of viral-induced encephalopathy wherein sensitivity to the locomotor and stereotypic behavioral effects of d-amphetamine and cocaine is enhanced (Solbrig et al., 1994, 1998), we identify a specific neurotrophin expression pattern triggered by striatal viral injury that increases tyrosine hydroxylase activity, an early step in DA synthesis, to produce a phenotype of enhanced amphetamine sensitivity. The reactive neurotrophin pattern provides a molecular framework for understanding how CNS viral injury, as well as other CNS adaptations producing similar growth factor activation profiles, may influence psychostimulant sensitivity. |Animals[MESH] |Blotting, Western[MESH] |Borna Disease/*metabolism[MESH] |Borna disease virus/pathogenicity[MESH] |Brain Chemistry[MESH] |Brain/drug effects/*metabolism/pathology/virology[MESH] |Central Nervous System Stimulants/pharmacology[MESH] |Corpus Striatum/drug effects/metabolism/ultrastructure/virology[MESH] |Dextroamphetamine/pharmacology[MESH] |Disease Susceptibility/virology[MESH] |Dose-Response Relationship, Drug[MESH] |Male[MESH] |Motor Activity/drug effects[MESH] |Nerve Growth Factors/*biosynthesis[MESH] |Phosphorylation[MESH] |Precipitin Tests[MESH] |Rats[MESH] |Rats, Inbred Lew[MESH] |Substance-Related Disorders/*metabolism[MESH]Neurotrophic factor expression after CNS viral injury produces enhance(epmc).pdf DeepDyve Pubget Overpricing