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10.1292/jvms.62.775

http://scihub22266oqcxt.onion/10.1292/jvms.62.775
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10945300!ä!10945300

suck abstract from ncbi


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pmid10945300      J+Vet+Med+Sci 2000 ; 62 (7): 775-8
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  • Antibodies to Borna disease virus in infected adult rats: an early appearance of anti-p10 antibody and recognition of novel virus-specific proteins in infected animal brain cells #MMPMID10945300
  • Watanabe M; Kobayashi T; Tomonaga K; Ikuta K
  • J Vet Med Sci 2000[Jul]; 62 (7): 775-8 PMID10945300show ga
  • The time course for appearance of antibodies to Borna disease virus (BDV) major antigens, p40, p24, p18 and p10 were investigated in BDV-inoculated adult rats by Western blotting. Anti-p10 antibodies were detected in sera as early as anti-p40 and -p24 antibodies at four or five weeks after inoculation. Furthermore, in addition to these major antigens of BDV, the rat serum could detect additional 80-, 58-, 43-, 20-, and 16-kDa proteins in BDV-infected cultured cells and/or animal brain cells by Western blot analysis. Of these proteins, the 20- and 16-kDa proteins were shown to be related to p24 protein by their reactivity with anti-p24 monoclonal antibody. Interestingly, the 58- and 24-kDa were found only in BDV-infected animal brain cells but not in cultured cells. The results in this study could provide a useful information on the mechanism for the viral replication and pathogenesis.
  • |Animals[MESH]
  • |Antibodies, Monoclonal[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |Antigens, Viral/analysis/immunology[MESH]
  • |Blotting, Western[MESH]
  • |Borna Disease/blood/*immunology[MESH]
  • |Borna disease virus/*immunology/isolation & purification[MESH]
  • |Brain/virology[MESH]
  • |Cells, Cultured[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Lew[MESH]


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