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10.1046/j.1523-1755.2000.00169.x http://scihub22266oqcxt.onion/10.1046/j.1523-1755.2000.00169.x 10886578!ä!10886578 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2000 ; 58 (1): 325-30 Nephropedia Template TP {{tp|p=10886578|t=2000. Interaction of cyclosporine and FK506 with diuretics in transplant patients |pdf=|usr=}}{{10886578}} gab.com Text Interaction of cyclosporine and FK506 with diuretics in transplant patients JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=10886578 #FOAvip BACKGROUND: The calcineurin inhibitors cyclosporine and FK506 are widely used for immunosuppression in solid organ transplantation. One of the side effects of these agents is renal magnesium wasting. The site of action and molecular mechanism of this effect are not known. We hypothesized that agents such as diuretics that cause renal magnesium wasting through a similar action would not have an additive effect on magnesium deficiency with calcineurin inhibitors. METHODS: The records of 50 heart transplant patients on calcineurin inhibitors were reviewed to determine levels of serum magnesium and required replacement dose of magnesium, diuretic usage, and other laboratory values. RESULTS: Loop diuretics did not change either the magnesium level or magnesium replacement requirements in patients on calcineurin inhibitors. In contrast, the thiazide diuretic resulted in an increase in serum magnesium and a decrease in magnesium replacement. Results were similar when the cyclosporine or FK506 groups were evaluated alone. Patients taking FK506 had lower serum magnesium values and higher requirements for magnesium replacement compared with patients taking cyclosporine. CONCLUSION: We conclude that calcineurin inhibitors and loop diuretics have a similar site of action. Twit Text FOAVip Interaction of cyclosporine and FK506 with diuretics in transplant patients ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=10886578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10886578 #FOAvip English Wikipedia <ref>{{Cite pmid|10886578}}</ref> Interaction of cyclosporine and FK506 with diuretics in transplant patients #MMPMID10886578 Arthur JM; Shamim S Kidney Int 2000[Jul]; 58 (1): 325-30 PMID10886578show ga BACKGROUND: The calcineurin inhibitors cyclosporine and FK506 are widely used for immunosuppression in solid organ transplantation. One of the side effects of these agents is renal magnesium wasting. The site of action and molecular mechanism of this effect are not known. We hypothesized that agents such as diuretics that cause renal magnesium wasting through a similar action would not have an additive effect on magnesium deficiency with calcineurin inhibitors. METHODS: The records of 50 heart transplant patients on calcineurin inhibitors were reviewed to determine levels of serum magnesium and required replacement dose of magnesium, diuretic usage, and other laboratory values. RESULTS: Loop diuretics did not change either the magnesium level or magnesium replacement requirements in patients on calcineurin inhibitors. In contrast, the thiazide diuretic resulted in an increase in serum magnesium and a decrease in magnesium replacement. Results were similar when the cyclosporine or FK506 groups were evaluated alone. Patients taking FK506 had lower serum magnesium values and higher requirements for magnesium replacement compared with patients taking cyclosporine. CONCLUSION: We conclude that calcineurin inhibitors and loop diuretics have a similar site of action. |*Benzothiadiazines[MESH] |*Heart Transplantation[MESH] |Analysis of Variance[MESH] |Calcineurin Inhibitors[MESH] |Cyclosporine/*therapeutic use[MESH] |Diuretics[MESH] |Drug Interactions[MESH] |Female[MESH] |Humans[MESH] |Immunosuppressive Agents/*therapeutic use[MESH] |Loop of Henle/drug effects/metabolism[MESH] |Magnesium/blood/therapeutic use[MESH] |Male[MESH] |Middle Aged[MESH] |Potassium/blood[MESH] |Retrospective Studies[MESH] |Sodium Chloride Symporter Inhibitors/*therapeutic use[MESH]Interaction of cyclosporine and FK506 with diuretics in transplant pat(epmc).pdf DeepDyve Pubget Overpricing