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10.1074/jbc.M001914200 http://scihub22266oqcxt.onion/10.1074/jbc.M001914200 10833514!ä!10833514 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2000 ; 275 (33): 25130-8 Nephropedia Template TP {{tp|p=10833514|t=2000. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing |pdf=|usr=}}{{10833514}} gab.com Text Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=10833514 #FOAvip During hypoxia, hypoxia-inducible factor-1alpha (HIF-1alpha) is required for induction of a variety of genes including erythropoietin and vascular endothelial growth factor. Hypoxia increases mitochondrial reactive oxygen species (ROS) generation at Complex III, which causes accumulation of HIF-1alpha protein responsible for initiating expression of a luciferase reporter construct under the control of a hypoxic response element. This response is lost in cells depleted of mitochondrial DNA (rho(0) cells). Overexpression of catalase abolishes hypoxic response element-luciferase expression during hypoxia. Exogenous H(2)O(2) stabilizes HIF-1alpha protein during normoxia and activates luciferase expression in wild-type and rho(0) cells. Isolated mitochondria increase ROS generation during hypoxia, as does the bacterium Paracoccus denitrificans. These findings reveal that mitochondria-derived ROS are both required and sufficient to initiate HIF-1alpha stabilization during hypoxia. Twit Text FOAVip Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=10833514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10833514 #FOAvip English Wikipedia <ref>{{Cite pmid|10833514}}</ref> Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing #MMPMID10833514 Chandel NS; McClintock DS; Feliciano CE; Wood TM; Melendez JA; Rodriguez AM; Schumacker PT J Biol Chem 2000[Aug]; 275 (33): 25130-8 PMID10833514show ga During hypoxia, hypoxia-inducible factor-1alpha (HIF-1alpha) is required for induction of a variety of genes including erythropoietin and vascular endothelial growth factor. Hypoxia increases mitochondrial reactive oxygen species (ROS) generation at Complex III, which causes accumulation of HIF-1alpha protein responsible for initiating expression of a luciferase reporter construct under the control of a hypoxic response element. This response is lost in cells depleted of mitochondrial DNA (rho(0) cells). Overexpression of catalase abolishes hypoxic response element-luciferase expression during hypoxia. Exogenous H(2)O(2) stabilizes HIF-1alpha protein during normoxia and activates luciferase expression in wild-type and rho(0) cells. Isolated mitochondria increase ROS generation during hypoxia, as does the bacterium Paracoccus denitrificans. These findings reveal that mitochondria-derived ROS are both required and sufficient to initiate HIF-1alpha stabilization during hypoxia. |*Hypoxia[MESH] |*Transcription Factors[MESH] |Androstadienes/pharmacology[MESH] |Animals[MESH] |Cell Line[MESH] |Cell Nucleus/metabolism[MESH] |Chelating Agents/pharmacology[MESH] |Cobalt/pharmacology[MESH] |Cytosol/chemistry[MESH] |DNA-Binding Proteins/*metabolism[MESH] |Deferoxamine/pharmacology[MESH] |Dose-Response Relationship, Drug[MESH] |Electron Transport Complex III/*chemistry/*metabolism[MESH] |Electron Transport Complex IV/metabolism[MESH] |Enzyme Inhibitors/pharmacology[MESH] |Genes, Reporter[MESH] |Humans[MESH] |Hydrogen Peroxide/metabolism[MESH] |Hypoxia-Inducible Factor 1[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit[MESH] |Immunoblotting[MESH] |Marine Toxins[MESH] |Mitochondria, Liver/metabolism[MESH] |Mitochondria/enzymology/*metabolism[MESH] |Models, Biological[MESH] |Nuclear Proteins/*metabolism[MESH] |Oxazoles/pharmacology[MESH] |Oxidation-Reduction[MESH] |Oxygen/metabolism[MESH] |Paracoccus denitrificans/metabolism[MESH] |Rats[MESH] |Reactive Oxygen Species/*metabolism[MESH] |Time Factors[MESH] |Transfection[MESH] |Tumor Cells, Cultured[MESH]Reactive oxygen species generated at mitochondrial complex III stabili(epmc).pdf DeepDyve Pubget Overpricing