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10.1006/bbrc.2000.2683 http://scihub22266oqcxt.onion/10.1006/bbrc.2000.2683 10814519!ä!10814519 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2000 ; 271 (3): 665-71 Nephropedia Template TP {{tp|p=10814519|t=2000. Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells |pdf=|usr=}}{{10814519}} gab.com Text Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=10814519 #FOAvip Heme oxygenase 1 (HO-1), a rate-limiting enzyme in heme catabolism, has been reported to be induced by hypoxia. Unexpectedly, here we show that expression of HO-1 mRNA is repressed by hypoxia in primary cultures of human umbilical vein endothelial cells (HUVECs), but is increased by cobalt chloride (CoCl(2)) that is known to mimic hypoxia. Under the culture conditions used, the DNA-binding and transactivation activities of hypoxia-inducible factor 1 were increased in HUVECs by hypoxia or CoCl(2). Therefore, hypoxia and cobalt showed opposing effects on HO-1 mRNA expression, despite activation of hypoxia-inducible factor 1. The half-life of HO-1 mRNA was not changed by hypoxia, but was significantly prolonged by CoCl(2). Hypoxia also represses HO-1 mRNA expression in human coronary artery endothelial cells and astrocytes. The repression of HO-1 expression may represent the adaptation to hypoxia in certain cell types. Twit Text FOAVip Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=10814519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10814519 #FOAvip English Wikipedia <ref>{{Cite pmid|10814519}}</ref> Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells #MMPMID10814519 Nakayama M; Takahashi K; Kitamuro T; Yasumoto K; Katayose D; Shirato K; Fujii-Kuriyama Y; Shibahara S Biochem Biophys Res Commun 2000[May]; 271 (3): 665-71 PMID10814519show ga Heme oxygenase 1 (HO-1), a rate-limiting enzyme in heme catabolism, has been reported to be induced by hypoxia. Unexpectedly, here we show that expression of HO-1 mRNA is repressed by hypoxia in primary cultures of human umbilical vein endothelial cells (HUVECs), but is increased by cobalt chloride (CoCl(2)) that is known to mimic hypoxia. Under the culture conditions used, the DNA-binding and transactivation activities of hypoxia-inducible factor 1 were increased in HUVECs by hypoxia or CoCl(2). Therefore, hypoxia and cobalt showed opposing effects on HO-1 mRNA expression, despite activation of hypoxia-inducible factor 1. The half-life of HO-1 mRNA was not changed by hypoxia, but was significantly prolonged by CoCl(2). Hypoxia also represses HO-1 mRNA expression in human coronary artery endothelial cells and astrocytes. The repression of HO-1 expression may represent the adaptation to hypoxia in certain cell types. |*Transcription Factors[MESH] |Cell Hypoxia[MESH] |Cells, Cultured[MESH] |Cobalt/pharmacology[MESH] |DNA-Binding Proteins/pharmacology[MESH] |Deferoxamine/pharmacology[MESH] |Gene Expression Regulation, Enzymologic/drug effects[MESH] |Heme Oxygenase (Decyclizing)/*genetics/metabolism[MESH] |Heme Oxygenase-1[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit[MESH] |Membrane Proteins[MESH] |Muscle, Smooth, Vascular/*enzymology[MESH] |Nuclear Proteins/analysis/pharmacology[MESH] |Oxygen/*metabolism[MESH]Repression of heme oxygenase-1 by hypoxia in vascular endothelial cell(epmc).pdf DeepDyve Pubget Overpricing