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10.1099/0022-1317-81-4-1017 http://scihub22266oqcxt.onion/10.1099/0022-1317-81-4-1017 10725428!ä!10725428 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Gen+Virol 2000 ; 81 (Pt 4): 1017-25 Nephropedia Template TP {{tp|p=10725428|t=2000. Integrity and full coding sequence of B19 virus DNA persisting in human synovial tissue |pdf=|usr=}}{{10725428}} gab.com Text Integrity and full coding sequence of B19 virus DNA persisting in human synovial tissue JO: J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=10725428 #FOAvip Primary infection by human parvovirus B19 is often accompanied by arthropathy of varying duration, of which the most severe cases can be indistinguishable from rheumatoid arthritis (RA). While this might seem to imply a role in RA pathogenesis, recent studies have verified long-term persistence of B19 DNA in synovial tissue not only in patients with rheumatoid or juvenile arthritis, but also in immunocompetent, non-arthritic individuals with a history of prior B19 infection. However, the latter data are based on PCR amplification of short segments of DNA, with little sequence information. We determined the nucleotide sequence and examined the integrity of the protein-coding regions of B19 genomes persisting in synovial tissue and compared the results with data from synovial tissues of recently infected patients. In synovium of both previously and recently infected subjects, the viral coding regions were found to be present in an apparently continuous, intact DNA molecule. Comparison with sequences reported from blood or bone marrow showed that the synoviotropism or persistence of the B19 virus DNA was not due to exceptional mutations or particular genotype variants. The synovial retention of full-length viral genomes may represent a physiological process functioning in long-term storage of foreign macromolecules in this tissue. Twit Text FOAVip Integrity and full coding sequence of B19 virus DNA persisting in human synovial tissue ????J Gen Virol http://www.kidney.de/pget.php?&tw=1&pmid=10725428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10725428 #FOAvip English Wikipedia <ref>{{Cite pmid|10725428}}</ref> Integrity and full coding sequence of B19 virus DNA persisting in human synovial tissue #MMPMID10725428 Hokynar K; Brunstein J; Soderlund-Venermo M; Kiviluoto O; Partio EK; Konttinen Y; Hedman K J Gen Virol 2000[Apr]; 81 (Pt 4): 1017-25 PMID10725428show ga Primary infection by human parvovirus B19 is often accompanied by arthropathy of varying duration, of which the most severe cases can be indistinguishable from rheumatoid arthritis (RA). While this might seem to imply a role in RA pathogenesis, recent studies have verified long-term persistence of B19 DNA in synovial tissue not only in patients with rheumatoid or juvenile arthritis, but also in immunocompetent, non-arthritic individuals with a history of prior B19 infection. However, the latter data are based on PCR amplification of short segments of DNA, with little sequence information. We determined the nucleotide sequence and examined the integrity of the protein-coding regions of B19 genomes persisting in synovial tissue and compared the results with data from synovial tissues of recently infected patients. In synovium of both previously and recently infected subjects, the viral coding regions were found to be present in an apparently continuous, intact DNA molecule. Comparison with sequences reported from blood or bone marrow showed that the synoviotropism or persistence of the B19 virus DNA was not due to exceptional mutations or particular genotype variants. The synovial retention of full-length viral genomes may represent a physiological process functioning in long-term storage of foreign macromolecules in this tissue. |Base Sequence[MESH] |Conserved Sequence[MESH] |DNA, Viral/analysis/*genetics[MESH] |Humans[MESH] |Molecular Sequence Data[MESH] |Parvovirus B19, Human/*genetics/isolation & purification[MESH] |Phylogeny[MESH] |Sequence Analysis[MESH]Integrity and full coding sequence of B19 virus DNA persisting in huma(epmc).pdf DeepDyve Pubget Overpricing