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10.1046/j.1523-1755.2000.00881.x http://scihub22266oqcxt.onion/10.1046/j.1523-1755.2000.00881.x 10652038!ä!10652038 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Kidney+Int 2000 ; 57 (2): 607-12 Nephropedia Template TP {{tp|p=10652038|t=2000. Potassium-magnesium citrate versus potassium chloride in thiazide-induced hypokalemia |pdf=|usr=}}{{10652038}} gab.com Text Potassium-magnesium citrate versus potassium chloride in thiazide-induced hypokalemia JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=10652038 #FOAvip BACKGROUND: The purpose of this study was to compare the value of potassium-magnesium citrate (KMgCit) with potassium chloride in overcoming thiazide-induced hypokalemia. METHODS: Sixty normal subjects first took hydrochlorothiazide (HCTZ; 50 mg/day). After three weeks of treatment (or earlier if hypokalemia developed), they were randomized to take KMgCit (42 mEq K, 21 mEq Mg, and 63 mEq citrate/day) or potassium chloride (42 mEq/day) for three weeks while continuing on HCTZ. RESULTS: KMgCit significantly increased the serum potassium concentration from 3.42 +/- 0.30 mEq/L on HCTZ alone to about 3.8 mEq/L (P < 0.001). Potassium chloride produced a similar increase in serum potassium concentration from 3.45 +/- 0.44 mEq/L to about 3.8 mEq/L (P < 0. 001). KMgCit significantly increased the serum magnesium concentration by 0.11 to 0.12 mEq/L (P < 0.01), whereas potassium chloride produced a marginal decline or no significant change. KMgCit was less effective than potassium chloride in correcting HCTZ-induced hypochloridemia and hyperbicarbonatemia. KMgCit, but not potassium chloride, significantly increased urinary pH (by about 0.6 unit), citrate (by about 260 mg/day), and urinary magnesium. CONCLUSIONS: KMgCit is equally effective as potassium chloride in correcting thiazide-induced hypokalemia. In addition, KMgCit, but not potassium chloride, produces a small but significant increase in serum magnesium concentration by delivering a magnesium load, and it confers alkalinizing and citraturic actions. Twit Text FOAVip Potassium-magnesium citrate versus potassium chloride in thiazide-induced hypokalemia ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=10652038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10652038 #FOAvip English Wikipedia <ref>{{Cite pmid|10652038}}</ref> Potassium-magnesium citrate versus potassium chloride in thiazide-induced hypokalemia #MMPMID10652038 Wuermser LA; Reilly C; Poindexter JR; Sakhaee K; Pak CY Kidney Int 2000[Feb]; 57 (2): 607-12 PMID10652038show ga BACKGROUND: The purpose of this study was to compare the value of potassium-magnesium citrate (KMgCit) with potassium chloride in overcoming thiazide-induced hypokalemia. METHODS: Sixty normal subjects first took hydrochlorothiazide (HCTZ; 50 mg/day). After three weeks of treatment (or earlier if hypokalemia developed), they were randomized to take KMgCit (42 mEq K, 21 mEq Mg, and 63 mEq citrate/day) or potassium chloride (42 mEq/day) for three weeks while continuing on HCTZ. RESULTS: KMgCit significantly increased the serum potassium concentration from 3.42 +/- 0.30 mEq/L on HCTZ alone to about 3.8 mEq/L (P < 0.001). Potassium chloride produced a similar increase in serum potassium concentration from 3.45 +/- 0.44 mEq/L to about 3.8 mEq/L (P < 0. 001). KMgCit significantly increased the serum magnesium concentration by 0.11 to 0.12 mEq/L (P < 0.01), whereas potassium chloride produced a marginal decline or no significant change. KMgCit was less effective than potassium chloride in correcting HCTZ-induced hypochloridemia and hyperbicarbonatemia. KMgCit, but not potassium chloride, significantly increased urinary pH (by about 0.6 unit), citrate (by about 260 mg/day), and urinary magnesium. CONCLUSIONS: KMgCit is equally effective as potassium chloride in correcting thiazide-induced hypokalemia. In addition, KMgCit, but not potassium chloride, produces a small but significant increase in serum magnesium concentration by delivering a magnesium load, and it confers alkalinizing and citraturic actions. |Adult[MESH] |Citrates/*administration & dosage/adverse effects/urine[MESH] |Diuretics[MESH] |Double-Blind Method[MESH] |Drug Combinations[MESH] |Female[MESH] |Humans[MESH] |Hydrochlorothiazide/*adverse effects[MESH] |Hydrogen-Ion Concentration[MESH] |Hypokalemia/*chemically induced/*drug therapy/urine[MESH] |Kidney Calculi/chemically induced[MESH] |Magnesium Compounds/*administration & dosage/adverse effects[MESH] |Magnesium/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Potassium Chloride/*administration & dosage/adverse effects[MESH] |Potassium Compounds/*administration & dosage/adverse effects[MESH]Potassium-magnesium citrate versus potassium chloride in thiazide-indu(epmc).pdf DeepDyve Pubget Overpricing