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10.1038/sj.bjc.6690734 http://scihub22266oqcxt.onion/10.1038/sj.bjc.6690734 10574242/?report=reader!2362903!10574242     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Cancer 1999 ; 81 (4): 586-91 Nephropedia Template TP {{tp|p=10574242|t=1999. Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing s group |pdf=|usr=}}{{10574242}} gab.com Text Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing s group JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=10574242 #FOAvip Esthesioneuroblastoma (ENB) is a rare, site-specific, locally aggressive neuronal malignancy so far thought to belong to primitive peripheral neuroectodermal tumour-Ewing's tumour (pPNETs-ETs). Its anatomical location, in addition to morphologic, immunophenotypic and ultrastructural features, suggests its origin in the neuronal or neuroendocrine cells of the olfactory epithelium. However, the cytogenetic and molecular data currently available appear controversial on the presence of the typical translocation t(11;22)(q24;q12) and of trisomy 8, chromosomal changes that characterize the tumours belonging to the pPNETs-ETs. Herein we have analysed five ENB tumour specimens for trisomy 8 by fluorescence in situ hybridization (FISH), for the presence of EWS gene rearrangements by FISH, reverse transcription polymerase chain reaction and Southern blot analyses, as well as for the expression of the Ewing sarcoma-associated MIC2 antigen by immunohistochemistry. Neither EWS/FLI-I, EWS/ERG and EWS/FEV fusion genes nor MIC2 expression were found in any tumour, whereas trisomy 8 was found in one case only. Moreover, DNA from three cases analysed by Southern blot did not show EWS gene rearrangements. Our results support the evidence that ENB is not a member of the pPNETs-ETs. Twit Text FOAVip Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing s group ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=10574242 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10574242 #FOAvip English Wikipedia <ref>{{Cite pmid|10574242}}</ref> Esthesioneuroblastoma is not a member of the primitive peripheral neuroectodermal tumour-Ewing s group #MMPMID10574242 Mezzelani A; Tornielli S; Minoletti F; Pierotti MA; Sozzi G; Pilotti S Br J Cancer 1999[Oct]; 81 (4): 586-91 PMID10574242show ga Esthesioneuroblastoma (ENB) is a rare, site-specific, locally aggressive neuronal malignancy so far thought to belong to primitive peripheral neuroectodermal tumour-Ewing's tumour (pPNETs-ETs). Its anatomical location, in addition to morphologic, immunophenotypic and ultrastructural features, suggests its origin in the neuronal or neuroendocrine cells of the olfactory epithelium. However, the cytogenetic and molecular data currently available appear controversial on the presence of the typical translocation t(11;22)(q24;q12) and of trisomy 8, chromosomal changes that characterize the tumours belonging to the pPNETs-ETs. Herein we have analysed five ENB tumour specimens for trisomy 8 by fluorescence in situ hybridization (FISH), for the presence of EWS gene rearrangements by FISH, reverse transcription polymerase chain reaction and Southern blot analyses, as well as for the expression of the Ewing sarcoma-associated MIC2 antigen by immunohistochemistry. Neither EWS/FLI-I, EWS/ERG and EWS/FEV fusion genes nor MIC2 expression were found in any tumour, whereas trisomy 8 was found in one case only. Moreover, DNA from three cases analysed by Southern blot did not show EWS gene rearrangements. Our results support the evidence that ENB is not a member of the pPNETs-ETs. |Adult[MESH] |Aged[MESH] |Chromosome Aberrations[MESH] |Esthesioneuroblastoma, Olfactory/chemistry/*classification/genetics[MESH] |Female[MESH] |Heterogeneous-Nuclear Ribonucleoproteins[MESH] |Humans[MESH] |Immunohistochemistry[MESH] |In Situ Hybridization[MESH] |Male[MESH] |Middle Aged[MESH] |Neuroectodermal Tumors, Primitive, Peripheral/*classification[MESH] |RNA-Binding Protein EWS[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH]Esthesioneuroblastoma is not a member of the primitive peripheral neur(epmc).pdf DeepDyve Pubget Overpricing