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http://scihub22266oqcxt.onion/ 10535325!ä!10535325 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\10535325.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Dev+Biol 1999 ; 43 (5): 463-8 Nephropedia Template TP {{tp|p=10535325|t=1999. Pax2 in development and renal disease |pdf=|usr=}}{{10535325}} gab.com Text Pax2 in development and renal disease JO: Int J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=10535325 #FOAvip Pax genes are associated with a variety of developmental mutations in mouse and man that are gene dosage sensitive, or haploinsufficient. The Pax2 gene encodes a DNA binding, transcription factor whose expression is essential for the development of the renal epithelium. Both gain and loss of function mutants in the mouse demonstrate a requirement for Pax2 in the conversion of metanephric mesenchymal precursor cells to the fully differentiated tubular epithelium of the nephron. However, Pax2 expression is down-regulated as cells leave the mitotic cycle. Humans carrying a single Pax2 mutant allele exhibit renal hypoplasia, vesicoureteric reflux, and optic nerve colobomas. Conversely, persistent expression of Pax2 has been demonstrated in a variety of cystic and dysplastic renal diseases and correlates with continued proliferation of renal epithelial cells. Thus, Pax2 misexpresssion may be a key determinant in the initiation and progression of renal diseases marked by increased or deregulated cell proliferation. Twit Text FOAVip Pax2 in development and renal disease ????Int J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=10535325 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10535325 #FOAvip English Wikipedia <ref>{{Cite pmid|10535325}}</ref> Pax2 in development and renal disease #MMPMID10535325 Dressler GR; Woolf AS Int J Dev Biol 1999[]; 43 (5): 463-8 PMID10535325show ga Pax genes are associated with a variety of developmental mutations in mouse and man that are gene dosage sensitive, or haploinsufficient. The Pax2 gene encodes a DNA binding, transcription factor whose expression is essential for the development of the renal epithelium. Both gain and loss of function mutants in the mouse demonstrate a requirement for Pax2 in the conversion of metanephric mesenchymal precursor cells to the fully differentiated tubular epithelium of the nephron. However, Pax2 expression is down-regulated as cells leave the mitotic cycle. Humans carrying a single Pax2 mutant allele exhibit renal hypoplasia, vesicoureteric reflux, and optic nerve colobomas. Conversely, persistent expression of Pax2 has been demonstrated in a variety of cystic and dysplastic renal diseases and correlates with continued proliferation of renal epithelial cells. Thus, Pax2 misexpresssion may be a key determinant in the initiation and progression of renal diseases marked by increased or deregulated cell proliferation. |Animals[MESH] |Coloboma/genetics[MESH] |DNA-Binding Proteins/*genetics/metabolism[MESH] |Embryonic and Fetal Development[MESH] |Gene Expression Regulation, Developmental[MESH] |Humans[MESH] |Kidney Neoplasms/*genetics/metabolism[MESH] |Kidney/*abnormalities/*embryology[MESH] |Mice[MESH] |PAX2 Transcription Factor[MESH] |Syndrome[MESH]Pax2 in development and renal disease (epmc).pdf DeepDyve Pubget Overpricing