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http://scihub22266oqcxt.onion/ 10535322!ä!10535322 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Dev+Biol 1999 ; 43 (5): 445-51 Nephropedia Template TP {{tp|p=10535322|t=1999. Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney |pdf=|usr=}}{{10535322}} gab.com Text Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney JO: Int J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=10535322 #FOAvip The molecular nature of the glomerular slit diaphragm, the site of renal ultrafiltration, has until recently remained a mystery. However, the identification of the gene affected in congenital nephrotic syndrome has revealed the presence of a novel protein, possibly specific for the slit diaphragm. This protein, which has been termed nephrin, is a transmembrane protein that probably forms the main building block of an isoporous zipper-like slit diaphragm filter structure. Defects in nephrin lead to abnormal or absent slit diaphragm leading to massive proteinuria and renal failure. The discovery of nephrin sheds new light on the glomerular filtration barrier, provides new insight into the pathomechanisms of proteinuria, and even opens up possibilities for the development of novel therapies for this common and severe kidney complication. Twit Text FOAVip Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney ????Int J Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=10535322 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10535322 #FOAvip English Wikipedia <ref>{{Cite pmid|10535322}}</ref> Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney #MMPMID10535322 Tryggvason K; Ruotsalainen V; Wartiovaara J Int J Dev Biol 1999[]; 43 (5): 445-51 PMID10535322show ga The molecular nature of the glomerular slit diaphragm, the site of renal ultrafiltration, has until recently remained a mystery. However, the identification of the gene affected in congenital nephrotic syndrome has revealed the presence of a novel protein, possibly specific for the slit diaphragm. This protein, which has been termed nephrin, is a transmembrane protein that probably forms the main building block of an isoporous zipper-like slit diaphragm filter structure. Defects in nephrin lead to abnormal or absent slit diaphragm leading to massive proteinuria and renal failure. The discovery of nephrin sheds new light on the glomerular filtration barrier, provides new insight into the pathomechanisms of proteinuria, and even opens up possibilities for the development of novel therapies for this common and severe kidney complication. |Animals[MESH] |Gene Expression[MESH] |Humans[MESH] |In Situ Hybridization[MESH] |Kidney Glomerulus/metabolism[MESH] |Kidney/*metabolism[MESH] |Membrane Proteins[MESH] |Microscopy, Immunoelectron[MESH] |Nephrotic Syndrome/congenital/*genetics/*metabolism[MESH]Discovery of the congenital nephrotic syndrome gene discloses the stru(epmc).pdf DeepDyve Pubget Overpricing