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10.1093/ndt/14.9.2119 http://scihub22266oqcxt.onion/10.1093/ndt/14.9.2119 10489220!ä!10489220 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nephrol+Dial+Transplant 1999 ; 14 (9): 2119-29 Nephropedia Template TP {{tp|p=10489220|t=1999. Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane |pdf=|usr=}}{{10489220}} gab.com Text Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane JO: Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=10489220 #FOAvip As the first barrier to be crossed on the way to urinary space, the glomerular basement membrane (GBM) plays a key role in renal function. The permeability of the GBM for a given molecule is highly dependent on its size, shape and charge. As early as 1980, the charge-selective permeability was demonstrated to relate to the electrostatic properties of covalently bound heparan sulfates (HS) within the GBM. Since the identification of perlecan as a heparan sulfate proteoglycan (HSPG) of basement membranes, the hypothesis that perlecan could be a crucial determinant of GBM permselectivity received considerable attention. In addition to perlecan, the GBM also contains other HSPG species, one of which was identified as agrin. The high local expression of agrin in the GBM, together with the presence of agrin receptors at the cell matrix interface, suggests that this HSPG contributes to glomerular function in multiple ways. Here, we review the current knowledge regarding the structure and functions of HSPGs in the GBM, and discuss how these molecules could be involved in various glomerular diseases. Possible directions for future investigation are suggested. Twit Text FOAVip Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane ????Nephrol Dial Transplant http://www.kidney.de/pget.php?&tw=1&pmid=10489220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10489220 #FOAvip English Wikipedia <ref>{{Cite pmid|10489220}}</ref> Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane #MMPMID10489220 Groffen AJ; Veerkamp JH; Monnens LA; van den Heuvel LP Nephrol Dial Transplant 1999[Sep]; 14 (9): 2119-29 PMID10489220show ga As the first barrier to be crossed on the way to urinary space, the glomerular basement membrane (GBM) plays a key role in renal function. The permeability of the GBM for a given molecule is highly dependent on its size, shape and charge. As early as 1980, the charge-selective permeability was demonstrated to relate to the electrostatic properties of covalently bound heparan sulfates (HS) within the GBM. Since the identification of perlecan as a heparan sulfate proteoglycan (HSPG) of basement membranes, the hypothesis that perlecan could be a crucial determinant of GBM permselectivity received considerable attention. In addition to perlecan, the GBM also contains other HSPG species, one of which was identified as agrin. The high local expression of agrin in the GBM, together with the presence of agrin receptors at the cell matrix interface, suggests that this HSPG contributes to glomerular function in multiple ways. Here, we review the current knowledge regarding the structure and functions of HSPGs in the GBM, and discuss how these molecules could be involved in various glomerular diseases. Possible directions for future investigation are suggested. |Animals[MESH] |Basement Membrane/*chemistry/*physiology[MESH] |Heparan Sulfate Proteoglycans/analysis/*chemistry/*physiology[MESH] |Humans[MESH] |Kidney Diseases/metabolism/physiopathology[MESH]Recent insights into the structure and functions of heparan sulfate pr(epmc).pdf DeepDyve Pubget Overpricing