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10.1164/ajrccm.159.6.9810087 http://scihub22266oqcxt.onion/10.1164/ajrccm.159.6.9810087 10351927!ä!10351927 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Crit+Care+Med 1999 ; 159 (6): 1830-4 Nephropedia Template TP {{tp|p=10351927|t=1999. Expression of costimulatory molecules on alveolar macrophages in hypersensitivity pneumonitis |pdf=|usr=}}{{10351927}} gab.com Text Expression of costimulatory molecules on alveolar macrophages in hypersensitivity pneumonitis JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=10351927 #FOAvip To verify whether alveolar macrophages (AM) of patients with hypersensitivity pneumonitis (HP) increase their antigen-presenting capacity by upregulating the expression of B7 costimulatory molecules (CD80, CD86), and whether a viral infection enhances this expression whereas cigarette smoking abrogates it, we performed bronchoalveolar lavage (BAL) on 18 patients with HP; 10 asymptomatic, virus-exposed subjects (AS); 18 nonsmokers; and 12 smokers. Influenza virus infection of AM from nonsmokers and smokers was induced in vitro. Expression of CD80 and CD86 on AM, and of CD28 and CTLA4 on T cells, was evaluated. The percentage of CD80(+) AM was greater in HP patients (34.6 +/- 7.7) and in AS (23.9 +/- 7.6) than in nonsmokers (6.7 +/- 1.6) or smokers (2.5 +/- 0.3). An increase in CD86(+) cells (62.3 +/- 5.9) was found in HP patients as compared with nonsmokers (24.2 +/- 3.8) and smokers (4.5 +/- 1.0). CD28 and CTLA4 molecules were highly expressed on all T cells. In vitro virus infection upregulated CD80 and CD86 expression in AM of normal nonsmoking subjects but not on those of smokers. These results suggest that: (1) an upregulation of B7 molecule expression is involved in the lymphocytic alveolitis of HP; (2) a viral infection could enhance HP by increasing B7 expression; and (3) the protective effect of cigarette smoking in HP may be due to the low level of expression of costimulatory molecules on AM from smokers, and to their resistance to further upregulation. Twit Text FOAVip Expression of costimulatory molecules on alveolar macrophages in hypersensitivity pneumonitis ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=10351927 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10351927 #FOAvip English Wikipedia <ref>{{Cite pmid|10351927}}</ref> Expression of costimulatory molecules on alveolar macrophages in hypersensitivity pneumonitis #MMPMID10351927 Israel-Assayag E; Dakhama A; Lavigne S; Laviolette M; Cormier Y Am J Respir Crit Care Med 1999[Jun]; 159 (6): 1830-4 PMID10351927show ga To verify whether alveolar macrophages (AM) of patients with hypersensitivity pneumonitis (HP) increase their antigen-presenting capacity by upregulating the expression of B7 costimulatory molecules (CD80, CD86), and whether a viral infection enhances this expression whereas cigarette smoking abrogates it, we performed bronchoalveolar lavage (BAL) on 18 patients with HP; 10 asymptomatic, virus-exposed subjects (AS); 18 nonsmokers; and 12 smokers. Influenza virus infection of AM from nonsmokers and smokers was induced in vitro. Expression of CD80 and CD86 on AM, and of CD28 and CTLA4 on T cells, was evaluated. The percentage of CD80(+) AM was greater in HP patients (34.6 +/- 7.7) and in AS (23.9 +/- 7.6) than in nonsmokers (6.7 +/- 1.6) or smokers (2.5 +/- 0.3). An increase in CD86(+) cells (62.3 +/- 5.9) was found in HP patients as compared with nonsmokers (24.2 +/- 3.8) and smokers (4.5 +/- 1.0). CD28 and CTLA4 molecules were highly expressed on all T cells. In vitro virus infection upregulated CD80 and CD86 expression in AM of normal nonsmoking subjects but not on those of smokers. These results suggest that: (1) an upregulation of B7 molecule expression is involved in the lymphocytic alveolitis of HP; (2) a viral infection could enhance HP by increasing B7 expression; and (3) the protective effect of cigarette smoking in HP may be due to the low level of expression of costimulatory molecules on AM from smokers, and to their resistance to further upregulation. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Antigens, CD/*metabolism[MESH] |B7-1 Antigen/*metabolism[MESH] |B7-2 Antigen[MESH] |Bronchoalveolar Lavage Fluid/chemistry/cytology[MESH] |Female[MESH] |Humans[MESH] |Influenza, Human/metabolism[MESH] |Lymphocytes/physiology[MESH] |Macrophages, Alveolar/*metabolism/physiology/virology[MESH] |Male[MESH] |Membrane Glycoproteins/*metabolism[MESH] |Middle Aged[MESH] |Phenotype[MESH] |Pneumonia/*etiology/*metabolism/pathology[MESH]Expression of costimulatory molecules on alveolar macrophages in hyper(epmc).pdf DeepDyve Pubget Overpricing