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10.1016/s0049-0172(99)80015-8

http://scihub22266oqcxt.onion/10.1016/s0049-0172(99)80015-8
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10342388!ä!10342388

suck abstract from ncbi


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pmid10342388      Semin+Arthritis+Rheum 1999 ; 28 (5): 314-8
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  • Parvovirus infection mimicking systemic lupus erythematosus in a pediatric population #MMPMID10342388
  • Moore TL; Bandlamudi R; Alam SM; Nesher G
  • Semin Arthritis Rheum 1999[Apr]; 28 (5): 314-8 PMID10342388show ga
  • OBJECTIVES: To assess the striking similarities of presentation in a pediatric population between human parvovirus B19 (HPV-B19) infection and systemic lupus erythematous (SLE). METHODS: Medical records of seven patients (ages 6 to 15) with HPV-B19 infection were reviewed retrospectively. RESULTS: Six of seven cases presented with a history of malar rash, and all seven had prolonged arthralgias and fatigue. Six of seven had a positive antinuclear antibody (ANA) titer ranging from 1:40 to greater than 1:640, with two patients having antibodies to Scl-70 and others to Sm, RNP, SS-A (Ro), or SS-B (La). The erythrocyte sedimentation rate (ESR) varied from 2 to 68 mm/h. Two patients presented with elevated rheumatoid factor (RF) titers of 24 and 271 IU/mL, respectively. All had elevated IgM antibody levels to parvovirus at the onset, and markedly elevated IgG levels when evaluated throughout their disease course. Over the course of 2 to 3 months, three improved, but the other four continued to have symptomatology for 14, 40, 78, and 120 weeks, respectively. Treatment was symptomatic, and no one developed classic SLE. CONCLUSIONS: HPV-B19 infection in a pediatric patient group may present with SLE-like symptomatology and positive serology suggestive of SLE. The course of the disease is usually self-limited, though it may be prolonged in some for up to 120 weeks.
  • |Adolescent[MESH]
  • |Antibodies, Antinuclear/blood[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |Child[MESH]
  • |Diagnosis, Differential[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lupus Erythematosus, Systemic/blood/*diagnosis[MESH]
  • |Male[MESH]
  • |Parvoviridae Infections/blood/*diagnosis[MESH]
  • |Parvovirus B19, Human/immunology/isolation & purification/*pathogenicity[MESH]


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