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http://scihub22266oqcxt.onion/ 10340472!ä!10340472 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cells 1999 ; 9 (2): 172-8 Nephropedia Template TP {{tp|p=10340472|t=1999. Aromatic hydrocarbon nuclear translocator as a common component for the hypoxia- and dioxin-induced gene expression |pdf=|usr=}}{{10340472}} gab.com Text Aromatic hydrocarbon nuclear translocator as a common component for the hypoxia- and dioxin-induced gene expression JO: Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=10340472 #FOAvip Aromatic hydrocarbon nuclear translocator (Arnt) is an ubiquitously expressed protein that contains basic helix-loop-helix (bHLH) and Per-AhR-Arnt-Sim (PAS) motifs. Other bHLH-PAS proteins, hypoxia-inducible factor-1alpha (HIF-1alpha) and aromatic hydrocarbon receptor (AhR) mediate hypoxia- and dioxin-signal pathway, respectively. Arnt has been identified as a heterodimerization partner for AhR. AhR/Arnt heterodimer binds the regulatory region of xenobiotic-induced genes and activates their transcription. Here, in vivo results provide evidence that Arnt is involved in not only xenobiotic- but also hypoxia-induced transcriptional activation. In hypoxic condition, Arnt dimerizes with HIF-1alpha to make HIF-1alpha/Arnt heterodimer which is able to bind hypoxia-responsive DNA elements. The HIF-1alpha/Arnt heterodimer functions as a transactivator for hypoxia-inducible genes. Given that the expression of Arnt is limited, HIF-1alpha may compete with AhR for recruiting Arnt as a heteromeric partner. Consistent with this idea, the results indicate that the hypoxic activation of HIF-1alpha reduces dioxin-induced AhR's function on the dioxin-responsive reporter gene and the endogenous gene. Twit Text FOAVip Aromatic hydrocarbon nuclear translocator as a common component for the hypoxia- and dioxin-induced gene expression ????Mol Cells http://www.kidney.de/pget.php?&tw=1&pmid=10340472 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10340472 #FOAvip English Wikipedia <ref>{{Cite pmid|10340472}}</ref> Aromatic hydrocarbon nuclear translocator as a common component for the hypoxia- and dioxin-induced gene expression #MMPMID10340472 Park H Mol Cells 1999[Apr]; 9 (2): 172-8 PMID10340472show ga Aromatic hydrocarbon nuclear translocator (Arnt) is an ubiquitously expressed protein that contains basic helix-loop-helix (bHLH) and Per-AhR-Arnt-Sim (PAS) motifs. Other bHLH-PAS proteins, hypoxia-inducible factor-1alpha (HIF-1alpha) and aromatic hydrocarbon receptor (AhR) mediate hypoxia- and dioxin-signal pathway, respectively. Arnt has been identified as a heterodimerization partner for AhR. AhR/Arnt heterodimer binds the regulatory region of xenobiotic-induced genes and activates their transcription. Here, in vivo results provide evidence that Arnt is involved in not only xenobiotic- but also hypoxia-induced transcriptional activation. In hypoxic condition, Arnt dimerizes with HIF-1alpha to make HIF-1alpha/Arnt heterodimer which is able to bind hypoxia-responsive DNA elements. The HIF-1alpha/Arnt heterodimer functions as a transactivator for hypoxia-inducible genes. Given that the expression of Arnt is limited, HIF-1alpha may compete with AhR for recruiting Arnt as a heteromeric partner. Consistent with this idea, the results indicate that the hypoxic activation of HIF-1alpha reduces dioxin-induced AhR's function on the dioxin-responsive reporter gene and the endogenous gene. |*Receptors, Aryl Hydrocarbon[MESH] |Animals[MESH] |Aryl Hydrocarbon Receptor Nuclear Translocator[MESH] |Cell Hypoxia/genetics/*physiology[MESH] |Cobalt/pharmacology[MESH] |Cytochrome P-450 CYP1A1/genetics[MESH] |DNA-Binding Proteins/metabolism[MESH] |DNA/genetics/metabolism[MESH] |Dimethyl Sulfoxide/pharmacology[MESH] |Dioxins/*pharmacology[MESH] |Gene Expression Regulation, Neoplastic[MESH] |Hypoxia-Inducible Factor 1[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit[MESH] |Nuclear Proteins/metabolism[MESH] |Phosphoglycerate Kinase/genetics[MESH] |Polychlorinated Dibenzodioxins/pharmacology[MESH] |Protein Binding[MESH] |RNA, Messenger/drug effects/genetics/metabolism[MESH] |Signal Transduction[MESH] |Transcription Factors/*physiology[MESH]Aromatic hydrocarbon nuclear translocator as a common component for th(epmc).pdf DeepDyve Pubget Overpricing