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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Brain+Res+Bull 1999 ; 48 (1): 23-30 Nephropedia Template TP
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Borna disease virus-induced hippocampal dentate gyrus damage is associated with spatial learning and memory deficits #MMPMID10210164
Rubin SA; Sylves P; Vogel M; Pletnikov M; Moran TH; Schwartz GJ; Carbone KM
Brain Res Bull 1999[Jan]; 48 (1): 23-30 PMID10210164show ga
In neonatally inoculated rats, Borna disease virus (BDV) leads to a persistent infection of the brain in the absence of an inflammatory response and is associated with neuroanatomic, developmental, physiologic, and behavioral abnormalities. One of the most dramatic sites of BDV-associated damage in the neonatal rat brain is the dentate gyrus, a neuroanatomic region believed to play a major role in spatial learning and memory. The absence of a generalized inflammatory response to neonatal BDV infection permits direct effects of viral damage to the dentate gyrus to be examined. In this report, neonatally BDV-infected rats at various stages of dentate gyrus degeneration were evaluated in the Morris water maze, a swimming test that assesses the rats' capacity to navigate by visual cues. Our data demonstrate progressive spatial learning and memory deficits in BDV-infected rats that coincided with a gradual decline in the estimated hippocampal dentate gyrus neuron density.