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10.1016/s0361-9230(98)00133-6

http://scihub22266oqcxt.onion/10.1016/s0361-9230(98)00133-6
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10210164!ä!10210164

suck abstract from ncbi


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pmid10210164      Brain+Res+Bull 1999 ; 48 (1): 23-30
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  • Borna disease virus-induced hippocampal dentate gyrus damage is associated with spatial learning and memory deficits #MMPMID10210164
  • Rubin SA; Sylves P; Vogel M; Pletnikov M; Moran TH; Schwartz GJ; Carbone KM
  • Brain Res Bull 1999[Jan]; 48 (1): 23-30 PMID10210164show ga
  • In neonatally inoculated rats, Borna disease virus (BDV) leads to a persistent infection of the brain in the absence of an inflammatory response and is associated with neuroanatomic, developmental, physiologic, and behavioral abnormalities. One of the most dramatic sites of BDV-associated damage in the neonatal rat brain is the dentate gyrus, a neuroanatomic region believed to play a major role in spatial learning and memory. The absence of a generalized inflammatory response to neonatal BDV infection permits direct effects of viral damage to the dentate gyrus to be examined. In this report, neonatally BDV-infected rats at various stages of dentate gyrus degeneration were evaluated in the Morris water maze, a swimming test that assesses the rats' capacity to navigate by visual cues. Our data demonstrate progressive spatial learning and memory deficits in BDV-infected rats that coincided with a gradual decline in the estimated hippocampal dentate gyrus neuron density.
  • |Animals[MESH]
  • |Borna Disease/complications/*pathology/*psychology[MESH]
  • |Dentate Gyrus/*pathology[MESH]
  • |Maze Learning/*physiology[MESH]
  • |Memory Disorders/*etiology[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Lew[MESH]


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