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10.1074/jbc.274.17.12115 http://scihub22266oqcxt.onion/10.1074/jbc.274.17.12115 10207038!ä!10207038 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 1999 ; 274 (17): 12115-23 Nephropedia Template TP {{tp|p=10207038|t=1999. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways Demonstration of competition and compensation |pdf=|usr=}}{{10207038}} gab.com Text Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways Demonstration of competition and compensation JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=10207038 #FOAvip The aryl hydrocarbon receptor (AHR) and the alpha-class hypoxia inducible factors (HIF1alpha, HIF2alpha, and HIF3alpha) are basic helix-loop-helix PAS (bHLH-PAS) proteins that heterodimerize with ARNT. In response to 2,3,7,8-tetrachlorodibenzo-p-dioxin, the AHR. ARNT complex binds to "dioxin responsive enhancers" (DREs) and activates genes involved in the metabolism of xenobiotics, e.g. cytochrome P4501A1 (Cyp1a1). The HIF1alpha.ARNT complex binds to "hypoxia responsive enhancers" and activates the transcription of genes that regulate adaptation to low oxygen, e.g. erythropoietin (Epo). We postulated that activation of one pathway would inhibit the other due to competition for ARNT or other limiting cellular factors. Using pathway specific reporters in transient transfection assays, we observed that DRE driven transcription was markedly inhibited by hypoxia and that hypoxia responsive enhancer driven transcription was inhibited by AHR agonists. When we attempted to support this cross-talk model using endogenous loci, we observed that activation of the hypoxia pathway inhibited Cyp1a1 up-regulation, but that activation of the AHR actually enhanced the induction of Epo by hypoxia. To explain this unexpected additivity, we examined the Epo gene and found that its promoter harbors DREs immediately upstream of its transcriptional start site. These experiments outline conditions where inhibitory and additive cross-talk occur between the hypoxia and dioxin signal transduction pathways and identify Epo as an AHR-regulated gene. Twit Text FOAVip Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways Demonstration of competition and compensation ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=10207038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10207038 #FOAvip English Wikipedia <ref>{{Cite pmid|10207038}}</ref> Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways Demonstration of competition and compensation #MMPMID10207038 Chan WK; Yao G; Gu YZ; Bradfield CA J Biol Chem 1999[Apr]; 274 (17): 12115-23 PMID10207038show ga The aryl hydrocarbon receptor (AHR) and the alpha-class hypoxia inducible factors (HIF1alpha, HIF2alpha, and HIF3alpha) are basic helix-loop-helix PAS (bHLH-PAS) proteins that heterodimerize with ARNT. In response to 2,3,7,8-tetrachlorodibenzo-p-dioxin, the AHR. ARNT complex binds to "dioxin responsive enhancers" (DREs) and activates genes involved in the metabolism of xenobiotics, e.g. cytochrome P4501A1 (Cyp1a1). The HIF1alpha.ARNT complex binds to "hypoxia responsive enhancers" and activates the transcription of genes that regulate adaptation to low oxygen, e.g. erythropoietin (Epo). We postulated that activation of one pathway would inhibit the other due to competition for ARNT or other limiting cellular factors. Using pathway specific reporters in transient transfection assays, we observed that DRE driven transcription was markedly inhibited by hypoxia and that hypoxia responsive enhancer driven transcription was inhibited by AHR agonists. When we attempted to support this cross-talk model using endogenous loci, we observed that activation of the hypoxia pathway inhibited Cyp1a1 up-regulation, but that activation of the AHR actually enhanced the induction of Epo by hypoxia. To explain this unexpected additivity, we examined the Epo gene and found that its promoter harbors DREs immediately upstream of its transcriptional start site. These experiments outline conditions where inhibitory and additive cross-talk occur between the hypoxia and dioxin signal transduction pathways and identify Epo as an AHR-regulated gene. |*Receptor Cross-Talk[MESH] |*Signal Transduction[MESH] |Base Sequence[MESH] |Binding, Competitive[MESH] |Cobalt/pharmacology[MESH] |Cytochrome P-450 CYP1A1/genetics[MESH] |DNA[MESH] |Dioxins/pharmacology[MESH] |Enhancer Elements, Genetic[MESH] |Erythropoietin/genetics[MESH] |Gene Expression Regulation, Enzymologic/drug effects[MESH] |Molecular Sequence Data[MESH] |Promoter Regions, Genetic[MESH] |RNA, Messenger/genetics[MESH] |Receptors, Aryl Hydrocarbon/genetics/*metabolism[MESH] |Transcription Factors/*metabolism[MESH]Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible(epmc).pdf DeepDyve Pubget Overpricing