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10.1086/513850

http://scihub22266oqcxt.onion/10.1086/513850
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10081503!ä!10081503

suck abstract from ncbi


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pmid10081503      J+Infect+Dis 1999 ; 179 Suppl 2 (ä): S326-30
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  • How intracellular bacteria survive: surface modifications that promote resistance to host innate immune responses #MMPMID10081503
  • Ernst RK; Guina T; Miller SI
  • J Infect Dis 1999[Mar]; 179 Suppl 2 (ä): S326-30 PMID10081503show ga
  • Bacterial pathogens regulate the expression of virulence factors in response to environmental signals. In the case of salmonellae, many virulence factors are regulated via PhoP/PhoQ, a two-component signal transduction system that is repressed by magnesium and calcium in vitro. PhoP/PhoQ-activated genes promote intracellular survival within macrophages, whereas PhoP-repressed genes promote entrance into epithelial cells and macrophages by macropinocytosis and stimulate epithelial cell cytokine production. PhoP-activated genes include those that alter the cell envelope through structural alterations of lipopolysaccharide and lipid A, the bioactive component of lipopolysaccharide. PhoP-activated changes in the bacterial envelope likely promote intracellular survival by increasing resistance to host cationic antimicrobial peptides and decreasing host cell cytokine production.
  • |Animals[MESH]
  • |Bacteria/genetics/*immunology/*pathogenicity[MESH]
  • |Bacterial Proteins/genetics/physiology[MESH]
  • |Carbohydrate Sequence[MESH]
  • |Genes, Bacterial[MESH]
  • |Humans[MESH]
  • |Lipopolysaccharides/chemistry/immunology[MESH]
  • |Molecular Sequence Data[MESH]
  • |Phagocytosis[MESH]
  • |Salmonella/genetics/immunology/pathogenicity[MESH]
  • |Signal Transduction[MESH]


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