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10.1016/s0264-410x(98)00223-0 http://scihub22266oqcxt.onion/10.1016/s0264-410x(98)00223-0 10073728!ä!10073728 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Vaccine 1999 ; 17 (5): 490-6 Nephropedia Template TP {{tp|p=10073728|t=1999. IL-6 induces long-term protective immunity against a lethal challenge of influenza virus |pdf=|usr=}}{{10073728}} gab.com Text IL-6 induces long-term protective immunity against a lethal challenge of influenza virus JO: Vaccine http://www.kidney.de/pget.php?&tw=1&pmid=10073728 #FOAvip The coadministration of cytokines can modulate immunity in DNA based viral vaccines. In order to determine the effects of various cytokines on long-term protection against the influenza virus, mice were intramuscularly coinoculated with plasmids that encoded either the granulocyte-macrophage colony-stimulating factor (GMCSF), interleukin-4 (IL-4), interleukin-12 (IL-12), or the interleukin-6 (IL-6) gene, in the presence of two plasmids that encoded the nucleoprotein (NP) and the hemagglutinin (HA) gene of the influenza A virus. The coadministration of IL-4, IL-6 and IL-12 transiently enhanced antibody responses against influenza virus in early time points (4 to 7 week post immunization) after post inoculation. The expression of GMCSF gene resulted in the sustained elevation of antibody responses for at least 20 weeks post inoculation. However, NP-specific CTL responses decreased in these animals. Mice that received either the IL-12 or the IL-6 gene had enhanced NP-specific CTL responses. Remarkably, the coadministration of the IL-6 gene completely protected mice from a lethal challenge with influenza virus. Conversely, mice that received the IL-4 gene appeared to be more susceptible to lethal challenge than mice that were inoculated with the NP and the HA genes alone. These results demonstrate that the use of cytokines as molecular adjuvants when coadministered in influenza DNA vaccination must be specific. Our data also demonstrates that the coadministration of IL-6 should be considered to enhance the efficacy of influenza DNA vaccines. Twit Text FOAVip IL-6 induces long-term protective immunity against a lethal challenge of influenza virus ????Vaccine http://www.kidney.de/pget.php?&tw=1&pmid=10073728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=10073728 #FOAvip English Wikipedia <ref>{{Cite pmid|10073728}}</ref> IL-6 induces long-term protective immunity against a lethal challenge of influenza virus #MMPMID10073728 Lee SW; Youn JW; Seong BL; Sung YC Vaccine 1999[Feb]; 17 (5): 490-6 PMID10073728show ga The coadministration of cytokines can modulate immunity in DNA based viral vaccines. In order to determine the effects of various cytokines on long-term protection against the influenza virus, mice were intramuscularly coinoculated with plasmids that encoded either the granulocyte-macrophage colony-stimulating factor (GMCSF), interleukin-4 (IL-4), interleukin-12 (IL-12), or the interleukin-6 (IL-6) gene, in the presence of two plasmids that encoded the nucleoprotein (NP) and the hemagglutinin (HA) gene of the influenza A virus. The coadministration of IL-4, IL-6 and IL-12 transiently enhanced antibody responses against influenza virus in early time points (4 to 7 week post immunization) after post inoculation. The expression of GMCSF gene resulted in the sustained elevation of antibody responses for at least 20 weeks post inoculation. However, NP-specific CTL responses decreased in these animals. Mice that received either the IL-12 or the IL-6 gene had enhanced NP-specific CTL responses. Remarkably, the coadministration of the IL-6 gene completely protected mice from a lethal challenge with influenza virus. Conversely, mice that received the IL-4 gene appeared to be more susceptible to lethal challenge than mice that were inoculated with the NP and the HA genes alone. These results demonstrate that the use of cytokines as molecular adjuvants when coadministered in influenza DNA vaccination must be specific. Our data also demonstrates that the coadministration of IL-6 should be considered to enhance the efficacy of influenza DNA vaccines. |Animals[MESH] |Antibodies, Viral/blood[MESH] |Cytokines/genetics/physiology[MESH] |Female[MESH] |Influenza Vaccines/*immunology[MESH] |Interleukin-6/genetics/*physiology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Orthomyxoviridae Infections/*immunology[MESH] |T-Lymphocytes, Cytotoxic/immunology[MESH]IL-6 induces long-term protective immunity against a lethal challenge (epmc).pdf DeepDyve Pubget Overpricing