Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi




http://scihub22266oqcxt.onion/
suck pdf from google scholar
1000507!ä!1000507

suck abstract from ncbi

pmid1000507
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Effect of hepatocarcinogens on the binding of glucocorticoid-receptor complex in rat liver nuclei #MMPMID1000507
  • Kensler TW; Busby WF Jr; Davidson NE; Wogan GN
  • Cancer Res 1976[Dec]; 36 (12): 4647-51 PMID1000507show ga
  • The effects of a number of carcinogens and hepatotoxins on the binding kinetics of the interactions of glucocorticoidcytosol receptor complex with nuclear acceptor sites in rat liver were investigated. Both the apparent sites in rat liver were investigated. Both the apparent concentration of nuclear binding sites and the Kd were significantly diminished following treatment of rats with sublethal doses of the carcinogens aflatoxin B1, diethylnitrosamine, dimethylnitrosamine, thioacetamide, 3'-methyl-4-dimethylaminoazobenzene, 4-dimethylaminoazobenzene, and 3-methylcholanthrene. Treatment with actinomycin D resulted in a slight reduction in the apparent concentration of nuclear acceptor sites but had no effect on the nuclear binding Kd. The hepatotoxic but noncarcinogenic analgesic, acetaminophen, as well as the weakly toxic aflatoxin B1 cognate, aflatoxin B2, were without effect on the kinetics or binding capacity of glucocorticoid-nuclear acceptor site interaction. These experiments suggest that chemically induced alteration of functional glucocorticoid binding sites on chromatin may be involved in the biochemical effects produced in liver by carcinogens of several chemical types. This experimental model may provide a useful approach for further elucidation of early events in carcinogenesis.
  • |*Receptors, Glucocorticoid/drug effects[MESH]
  • |*Receptors, Steroid[MESH]
  • |Alkylation[MESH]
  • |Animals[MESH]
  • |Binding Sites[MESH]
  • |Carcinogens/metabolism/*pharmacology[MESH]
  • |Cell Nucleus/metabolism[MESH]
  • |Cytosol/metabolism[MESH]
  • |DNA/metabolism[MESH]
  • |Dactinomycin/pharmacology[MESH]
  • |Dexamethasone/*metabolism[MESH]
  • |Kinetics[MESH]
  • |Liver/drug effects/*metabolism[MESH]
  • |Male[MESH]
  • |Rats[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    4647 12.36 1976