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10.1038/mtna.2015.23 http://scihub22266oqcxt.onion/10.1038/mtna.2015.23 C4877448!4877448!26372022     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26372022.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Ther+Nucleic+Acids 2015 ; 4 (9): e252- Nephropedia Template TP {{tp|p=26372022|t=2015. siRNA Versus miRNA as Therapeutics for Gene Silencing |pdf=|usr=}}{{26372022}} gab.com Text siRNA Versus miRNA as Therapeutics for Gene Silencing JO: Mol Ther Nucleic Acids http://www.kidney.de/pget.php?&tw=1&pmid=26372022 #FOAvip Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently been investigated as novel classes of therapeutic agents for the treatment of a wide range of disorders including cancers and infections. Clinical trials of siRNA- and miRNA-based drugs have already been initiated. siRNAs and miRNAs share many similarities, both are short duplex RNA molecules that exert gene silencing effects at the post-transcriptional level by targeting messenger RNA (mRNA), yet their mechanisms of action and clinical applications are distinct. The major difference between siRNAs and miRNAs is that the former are highly specific with only one mRNA target, whereas the latter have multiple targets. The therapeutic approaches of siRNAs and miRNAs are therefore very different. Hence, this review provides a comparison between therapeutic siRNAs and miRNAs in terms of their mechanisms of action, physicochemical properties, delivery, and clinical applications. Moreover, the challenges in developing both classes of RNA as therapeutics are also discussed. Twit Text FOAVip siRNA Versus miRNA as Therapeutics for Gene Silencing ????Mol Ther Nucleic Acids http://www.kidney.de/pget.php?&tw=1&pmid=26372022 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26372022 #FOAvip English Wikipedia <ref>{{Cite pmid|26372022}}</ref> siRNA Versus miRNA as Therapeutics for Gene Silencing #MMPMID26372022 Lam JKW; Chow MYT; Zhang Y; Leung SWS Mol Ther Nucleic Acids 2015[Sep]; 4 (9): e252- PMID26372022show ga Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently been investigated as novel classes of therapeutic agents for the treatment of a wide range of disorders including cancers and infections. Clinical trials of siRNA- and miRNA-based drugs have already been initiated. siRNAs and miRNAs share many similarities, both are short duplex RNA molecules that exert gene silencing effects at the post-transcriptional level by targeting messenger RNA (mRNA), yet their mechanisms of action and clinical applications are distinct. The major difference between siRNAs and miRNAs is that the former are highly specific with only one mRNA target, whereas the latter have multiple targets. The therapeutic approaches of siRNAs and miRNAs are therefore very different. Hence, this review provides a comparison between therapeutic siRNAs and miRNAs in terms of their mechanisms of action, physicochemical properties, delivery, and clinical applications. Moreover, the challenges in developing both classes of RNA as therapeutics are also discussed. äsiRNA Versus miRNA as Therapeutics for Gene Silencing (epmc).pdf DeepDyve Pubget Overpricing