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10.1007/978-94-017-9211-0_13 http://scihub22266oqcxt.onion/10.1007/978-94-017-9211-0_13 C5507576!5507576!25201198     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25201198.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Subcell+Biochem 2014 ; 85 (ä): 235-46 Nephropedia Template TP {{tp|p=25201198|t=2014. p53-Independent Effects of Mdm2 |pdf=|usr=}}{{25201198}} gab.com Text p53-Independent Effects of Mdm2 JO: Subcell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=25201198 #FOAvip Mdm2 is best known as the primary negative regulator of p53, but a growing body of evidence suggests that Mdm2 also has a number of functions independent of its role in regulating p53. Although these functions are not yet well-characterized, they have been implicated in regulating of a number of cellular processes, including cell-cycle control, apoptosis, differentiation, genome stability, and transcription, among others. It appears that Mdm2 exerts these functions through a surprisingly wide variety of mechanisms. For example, it has been shown that Mdm2 can ubiquitinate alternative targets, can stimulate the activity of transcription factors, and can directly bind to mRNA to regulate its stability. Dysregulation of p53-independent functions could be responsible for the oncogenic properties of Mdm2 seen even in the absence of p53, and may explain why approximately 10 % of human tumors overexpress Mdm2 instead of inactivating p53 through other mechanisms. As the p53-independent functions of Mdm2 present novel targets for potential therapeutic interventions, fully characterizing these cellular and pathogenic roles of Mdm2 will be important in the study of tumor biology and the treatment of cancer. Twit Text FOAVip p53-Independent Effects of Mdm2 ????Subcell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=25201198 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25201198 #FOAvip English Wikipedia <ref>{{Cite pmid|25201198}}</ref> p53-Independent Effects of Mdm2 #MMPMID25201198 Bohlman S; Manfredi JJ Subcell Biochem 2014[]; 85 (ä): 235-46 PMID25201198show ga Mdm2 is best known as the primary negative regulator of p53, but a growing body of evidence suggests that Mdm2 also has a number of functions independent of its role in regulating p53. Although these functions are not yet well-characterized, they have been implicated in regulating of a number of cellular processes, including cell-cycle control, apoptosis, differentiation, genome stability, and transcription, among others. It appears that Mdm2 exerts these functions through a surprisingly wide variety of mechanisms. For example, it has been shown that Mdm2 can ubiquitinate alternative targets, can stimulate the activity of transcription factors, and can directly bind to mRNA to regulate its stability. Dysregulation of p53-independent functions could be responsible for the oncogenic properties of Mdm2 seen even in the absence of p53, and may explain why approximately 10 % of human tumors overexpress Mdm2 instead of inactivating p53 through other mechanisms. As the p53-independent functions of Mdm2 present novel targets for potential therapeutic interventions, fully characterizing these cellular and pathogenic roles of Mdm2 will be important in the study of tumor biology and the treatment of cancer. äp53-Independent Effects of Mdm2 (epmc).pdf DeepDyve Pubget Overpricing