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2018 ; 10
(5
): ä Nephropedia Template TP
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English Wikipedia
p53-Autophagy-Metastasis Link
#MMPMID29783720
Denisenko TV
; Pivnyuk AD
; Zhivotovsky B
Cancers (Basel)
2018[May]; 10
(5
): ä PMID29783720
show ga
The tumor suppressor p53 as the "guardian of the genome" plays an essential role
in numerous signaling pathways that control the cell cycle, cell death and in
maintaining the integrity of the human genome. p53, depending on the
intracellular localization, contributes to the regulation of various cell death
pathways, including apoptosis, autophagy and necroptosis. Accumulated evidence
suggests that this function of p53 is closely involved in the process of cancer
development. Here, present knowledge concerning a p53-autophagy-metastasis link,
as well as therapeutic approaches that influence this link, are discussed.