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10.1038/ncomms11091 http://scihub22266oqcxt.onion/10.1038/ncomms11091 C4821997!4821997 !27033104     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27033104 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27033104 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 11091 Nephropedia Template TP {{tp|p=27033104 |t=2016. p53 downregulates the Fanconi anaemia DNA repair pathway |pdf=|usr=}}{{27033104 }} gab.com Text p53 downregulates the Fanconi anaemia DNA repair pathway JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27033104 #FOAvip Germline mutations affecting telomere maintenance or DNA repair may, respectively, cause dyskeratosis congenita or Fanconi anaemia, two clinically related bone marrow failure syndromes. Mice expressing p53(?31), a mutant p53 lacking the C terminus, model dyskeratosis congenita. Accordingly, the increased p53 activity in p53(?31/?31) fibroblasts correlated with a decreased expression of 4 genes implicated in telomere syndromes. Here we show that these cells exhibit decreased mRNA levels for additional genes contributing to telomere metabolism, but also, surprisingly, for 12 genes mutated in Fanconi anaemia. Furthermore, p53(?31/?31) fibroblasts exhibit a reduced capacity to repair DNA interstrand crosslinks, a typical feature of Fanconi anaemia cells. Importantly, the p53-dependent downregulation of Fanc genes is largely conserved in human cells. Defective DNA repair is known to activate p53, but our results indicate that, conversely, an increased p53 activity may attenuate the Fanconi anaemia DNA repair pathway, defining a positive regulatory feedback loop. Twit Text FOAVip p53 downregulates the Fanconi anaemia DNA repair pathway ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27033104 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27033104 #FOAvip English Wikipedia <ref>{{Cite pmid|27033104 }}</ref> p53 downregulates the Fanconi anaemia DNA repair pathway #MMPMID27033104 Jaber S ; Toufektchan E ; Lejour V ; Bardot B ; Toledo F Nat Commun 2016[Apr]; 7 (ä): 11091 PMID27033104 show ga Germline mutations affecting telomere maintenance or DNA repair may, respectively, cause dyskeratosis congenita or Fanconi anaemia, two clinically related bone marrow failure syndromes. Mice expressing p53(?31), a mutant p53 lacking the C terminus, model dyskeratosis congenita. Accordingly, the increased p53 activity in p53(?31/?31) fibroblasts correlated with a decreased expression of 4 genes implicated in telomere syndromes. Here we show that these cells exhibit decreased mRNA levels for additional genes contributing to telomere metabolism, but also, surprisingly, for 12 genes mutated in Fanconi anaemia. Furthermore, p53(?31/?31) fibroblasts exhibit a reduced capacity to repair DNA interstrand crosslinks, a typical feature of Fanconi anaemia cells. Importantly, the p53-dependent downregulation of Fanc genes is largely conserved in human cells. Defective DNA repair is known to activate p53, but our results indicate that, conversely, an increased p53 activity may attenuate the Fanconi anaemia DNA repair pathway, defining a positive regulatory feedback loop. |*DNA Repair [MESH] |*Down-Regulation [MESH] |Animals [MESH] |Cells, Cultured [MESH] |E2F4 Transcription Factor/genetics/metabolism/physiology [MESH] |Fanconi Anemia Complementation Group D2 Protein/genetics/metabolism/physiology [MESH] |Fanconi Anemia/*genetics [MESH] |Humans [MESH] |Mice [MESH] |NIH 3T3 Cells [MESH] |Transcriptome [MESH]p53 downregulates the Fanconi anaemia DNA repair pathway (epmc).pdf DeepDyve Pubget Overpricing