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10.1371/journal.pone.0139587 http://scihub22266oqcxt.onion/10.1371/journal.pone.0139587 C4595286!4595286 !26440672     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26440672 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26440672 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (10 ): e0139587 Nephropedia Template TP {{tp|p=26440672 |t=2015. ?Organo: A LegoŽ-Like Plug & Play System for Modular Multi-Organ-Chips |pdf=|usr=}}{{26440672 }} gab.com Text Organo: A LegoŽ-Like Plug & Play System for Modular Multi-Organ-Chips JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26440672 #FOAvip Human organ-on-a-chip systems for drug screening have evolved as feasible alternatives to animal models, which are unreliable, expensive, and at times erroneous. While chips featuring single organs can be of great use for both pharmaceutical testing and basic organ-level studies, the huge potential of the organ-on-a-chip technology is revealed by connecting multiple organs on one chip to create a single integrated system for sophisticated fundamental biological studies and devising therapies for disease. Furthermore, since most organ-on-a-chip systems require special protocols with organ-specific media for the differentiation and maturation of the tissues, multi-organ systems will need to be temporally customizable and flexible in terms of the time point of connection of the individual organ units. We present a customizable LegoŽ-like plug & play system, ?Organo, which enables initial individual culture of single organ-on-a-chip systems and subsequent connection to create integrated multi-organ microphysiological systems. As a proof of concept, the ?Organo system was used to connect multiple heart chips in series with excellent cell viability and spontaneously physiological beat rates. Twit Text FOAVip Organo: A LegoŽ-Like Plug & Play System for Modular Multi-Organ-Chips ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26440672 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26440672 #FOAvip English Wikipedia <ref>{{Cite pmid|26440672 }}</ref> ?Organo: A LegoŽ-Like Plug & Play System for Modular Multi-Organ-Chips #MMPMID26440672 Loskill P ; Marcus SG ; Mathur A ; Reese WM ; Healy KE PLoS One 2015[]; 10 (10 ): e0139587 PMID26440672 show ga Human organ-on-a-chip systems for drug screening have evolved as feasible alternatives to animal models, which are unreliable, expensive, and at times erroneous. While chips featuring single organs can be of great use for both pharmaceutical testing and basic organ-level studies, the huge potential of the organ-on-a-chip technology is revealed by connecting multiple organs on one chip to create a single integrated system for sophisticated fundamental biological studies and devising therapies for disease. Furthermore, since most organ-on-a-chip systems require special protocols with organ-specific media for the differentiation and maturation of the tissues, multi-organ systems will need to be temporally customizable and flexible in terms of the time point of connection of the individual organ units. We present a customizable LegoŽ-like plug & play system, ?Organo, which enables initial individual culture of single organ-on-a-chip systems and subsequent connection to create integrated multi-organ microphysiological systems. As a proof of concept, the ?Organo system was used to connect multiple heart chips in series with excellent cell viability and spontaneously physiological beat rates. |*Drug Evaluation, Preclinical [MESH] |Animals [MESH] |Heart [MESH] |Heart Rate/physiology [MESH] |Humans [MESH]?Organo: A LegoŽ-Like Plug & Play System for Modular Multi-Organ-Chips(epmc).pdf DeepDyve Pubget Overpricing