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2017 ; 8
(1
): 110
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microRNAs: important regulators of stem cells
#MMPMID28494789
Li N
; Long B
; Han W
; Yuan S
; Wang K
Stem Cell Res Ther
2017[May]; 8
(1
): 110
PMID28494789
show ga
Stem cells are undifferentiated cells and have multi-lineage differentiation
potential. Generally, stem cells are classified into adult stem cells, embryonic
stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Stem cells have
great potential in clinical therapy due to their pluripotency and self-renewal
ability. microRNAs (miRNAs) are small non-coding RNAs which are evolutionarily
conserved and participate in the pathogenesis of many diseases, cell cycle
regulation, apoptosis, aging, cell fate decisions, and different signaling
pathways. Different kinds of stem cells possess distinct miRNA expression
profiles. Our review summarizes the critical roles of miRNAs in stem cell
reprogramming, pluripotency maintenance, and differentiation. In the future,
miRNAs may greatly contribute to stem cell clinical therapy and have potential
applications in regenerative medicine.