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2015 ; 7
(7
): a008144
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microRNAs as Developmental Regulators
#MMPMID26134312
Ivey KN
; Srivastava D
Cold Spring Harb Perspect Biol
2015[Jul]; 7
(7
): a008144
PMID26134312
show ga
The field of miRNA biology is relatively young, but its impact on our
understanding of the regulation of a wide array of cell functions is
far-reaching. The importance of miRNAs in development has become nearly
ubiquitous, with miRNAs contributing to development of most cells and organs.
Although miRNAs are clearly interwoven into known regulatory networks that
control cell development, the specific modalities by which they intersect are
often quite distinct and cleverly achieved. The frequently emerging theme of
feed-back and feed-forward loops to either counterbalance or reinforce the gene
programs that they influence is a common thread. Many of these examples of miRNAs
as developmental regulators are presently found in organs with different miRNAs
and targets, whereas novel, unexpected themes emerge in the context of mouse
development as we learn more about this rapidly developing area of biology.
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