Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25831237
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25831237
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncotarget
2015 ; 6
(11
): 9257-70
Nephropedia Template TP
Huang D
; Qiu S
; Ge R
; He L
; Li M
; Li Y
; Peng Y
Oncotarget
2015[Apr]; 6
(11
): 9257-70
PMID25831237
show ga
Deregulation of microRNAs (miRs) contributes to tumorigenesis. Down-regulation of
miR-340 is observed in multiple types of cancers. However, the biological
function of miR-340 in glioblastoma multiforme (GBM) remains largely unknown. In
the present study, we demonstrated that expression of miR-340 was downregulated
in both glioma cell lines and tissues. Survival of GBM patients with high levels
of miR-340 was significantly extended in comparison to patients expressing low
miR-340 levels. Biological functional experiments showed that the restoration of
miR-340 dramatically inhibited glioma cell proliferation, induced cell-cycle
arrest and apoptosis, suppressed cell motility and promoted autophagy and
terminal differentiation. Mechanistic studies disclosed that, miR-340
over-expression suppressed several oncogenes including p-AKT, EZH2, EGFR, BMI1
and XIAP. Furthermore, ROCK1 was validated as a direct functional target miR-340
and silencing of ROCK1 phenocopied the anti-tumor effect of mR-340. Our findings
indicate an important role of miR-340 as a glioma killer, and suggest a potential
prognosis biomarker and therapeutic target for GBM.
free
free
free
