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2018 ; 9
(4
): 667-673
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mTOR signaling-related MicroRNAs and Cancer involvement
#MMPMID29556324
Wang P
; Liu XM
; Ding L
; Zhang XJ
; Ma ZL
J Cancer
2018[]; 9
(4
): 667-673
PMID29556324
show ga
MicroRNAs (miRNAs) are a class of single-stranded RNAs, 18-23 nucleotides in
length that regulate gene expression at the post-transcriptional level.
Dysregulation of miRNAs has been closely associated with the development of
cancer. In the process of tumorigenesis, mammalian target of rapamycin (mTOR)
plays important roles, and the mTOR signaling pathway is aberrant in various
types of human cancers, including non-small cell lung cancer (NSCLC), breast
cancer, prostate cancer, as well as others. However, the relationship between
miRNAs and the mTOR signaling pathway is indistinct. Herein, we not only
summarize the progress of miRNAs and the mTOR signaling pathway in cancers, but
also highlight their role in the diagnosis and treatment in the clinic.