Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25450580
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biochim+Biophys+Acta
2014 ; 1846
(2
): 638-54
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
mTOR signaling in tumorigenesis
#MMPMID25450580
Xu K
; Liu P
; Wei W
Biochim Biophys Acta
2014[Dec]; 1846
(2
): 638-54
PMID25450580
show ga
mTOR (the mechanistic target of rapamycin) is an atypical serine/threonine kinase
involved in regulating major cellular functions including growth and
proliferation. Deregulation of the mTOR signaling pathway is one of the most
commonly observed pathological alterations in human cancers. To this end,
oncogenic activation of the mTOR signaling pathway contributes to cancer cell
growth, proliferation and survival, highlighting the potential for targeting the
oncogenic mTOR pathway members as an effective anti-cancer strategy. In order to
do so, a thorough understanding of the physiological roles of key mTOR signaling
pathway components and upstream regulators would guide future targeted therapies.
Thus, in this review, we summarize available genetic mouse models for mTORC1 and
mTORC2 components, as well as characterized mTOR upstream regulators and
downstream targets, and assign a potential oncogenic or tumor suppressive role
for each evaluated molecule. Together, our work will not only facilitate the
current understanding of mTOR biology and possible future research directions,
but more importantly, provide a molecular basis for targeted therapies aiming at
key oncogenic members along the mTOR signaling pathway.
|*Carcinogenesis
[MESH]
|AMP-Activated Protein Kinases/physiology
[MESH]
|Adaptor Proteins, Signal Transducing/physiology
[MESH]
|Animals
[MESH]
|Autophagy
[MESH]
|Carrier Proteins/physiology
[MESH]
|Humans
[MESH]
|Mice
[MESH]
|Rapamycin-Insensitive Companion of mTOR Protein
[MESH]
free
free
free
