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10.1002/jcp.24351 http://scihub22266oqcxt.onion/10.1002/jcp.24351 C4491917!4491917 !23460185     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23460185 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Cell+Physiol 2013 ; 228 (8 ): 1658-64 Nephropedia Template TP {{tp|p=23460185 |t=2013. mTOR signaling for biological control and cancer |pdf=|usr=}}{{23460185 }} gab.com Text mTOR signaling for biological control and cancer JO: J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23460185 #FOAvip Mammalian target of rapamycin (mTOR) is a major intersection that connects signals from the extracellular milieu to corresponding changes in intracellular processes. When abnormally regulated, the mTOR signaling pathway is implicated in a wide spectrum of cancers, neurological diseases, and proliferative disorders. Therefore, pharmacological agents that restore the regulatory balance of the mTOR pathway could be beneficial for a great number of diseases. This review summarizes current understanding of mTOR signaling and some unanswered questions in the field. We describe the composition of the mTOR complexes, upstream signals that activate mTOR, and physiological processes that mTOR regulates. We also discuss the role of mTOR and its downstream effectors in cancer, obesity and diabetes, and autism. Twit Text FOAVip mTOR signaling for biological control and cancer ????J Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23460185 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23460185 #FOAvip English Wikipedia <ref>{{Cite pmid|23460185 }}</ref> mTOR signaling for biological control and cancer #MMPMID23460185 Alayev A ; Holz MK J Cell Physiol 2013[Aug]; 228 (8 ): 1658-64 PMID23460185 show ga Mammalian target of rapamycin (mTOR) is a major intersection that connects signals from the extracellular milieu to corresponding changes in intracellular processes. When abnormally regulated, the mTOR signaling pathway is implicated in a wide spectrum of cancers, neurological diseases, and proliferative disorders. Therefore, pharmacological agents that restore the regulatory balance of the mTOR pathway could be beneficial for a great number of diseases. This review summarizes current understanding of mTOR signaling and some unanswered questions in the field. We describe the composition of the mTOR complexes, upstream signals that activate mTOR, and physiological processes that mTOR regulates. We also discuss the role of mTOR and its downstream effectors in cancer, obesity and diabetes, and autism. |Animals [MESH] |Humans [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mechanistic Target of Rapamycin Complex 2 [MESH] |Multiprotein Complexes/antagonists & inhibitors/physiology [MESH] |Neoplasms/*enzymology [MESH] |Signal Transduction/*physiology [MESH]mTOR signaling for biological control and cancer (epmc).pdf DeepDyve Pubget Overpricing