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2016 ; 13
(9
): 756-9
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m(6)A: Signaling for mRNA splicing
#MMPMID27351695
Adhikari S
; Xiao W
; Zhao YL
; Yang YG
RNA Biol
2016[Sep]; 13
(9
): 756-9
PMID27351695
show ga
Among myriads of distinct chemical modifications in RNAs, dynamic
N6-methyladenosine (m(6)A) is one of the most prevalent modifications in
eukaryotic mRNAs and non-coding RNAs. Similar to the critical role of chemical
modifications in regulation of DNA and protein activities, RNA m(6)A modification
is also observed to be involved in the regulation of diverse functions of RNAs
including meiosis, fertility, development, cell reprogramming and circadian
period. The RNA m(6)A modification is recognized by YTH domain containing family
proteins comprising of YTHDC1-2 and YTHDF1-3. Here we focus on the nuclear m(6)A
reader YTHDC1 and its regulatory role in alternative splicing and other RNA
metabolic processes.