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2016 ; 99
(5
): 494-501
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lncRNA/MicroRNA interactions in the vasculature
#MMPMID26910520
Ballantyne MD
; McDonald RA
; Baker AH
Clin Pharmacol Ther
2016[May]; 99
(5
): 494-501
PMID26910520
show ga
MicroRNA (miRNA) have gained widespread attention for their role in diverse
vascular processes including angiogenesis, apoptosis, proliferation, and
migration. Despite great understanding of miRNA expression and function,
knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains
limited. The influence of miRNA on lncRNA function, and the converse, is now
beginning to emerge. lncRNA may regulate miRNA function by acting as endogenous
sponges to regulate gene expression and miRNA have been shown to bind and
regulate lncRNA stability. A detailed understanding of the molecular and cellular
effects of lncRNA-miRNA-mediated interactions in vascular pathophysiology could
pave the way for new diagnostic markers and therapeutic approaches, but first
there is a requirement for a more detailed understanding of the impact of such
regulatory networks.