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10.4062/biomolther.2015.149 http://scihub22266oqcxt.onion/10.4062/biomolther.2015.149 C4774490!4774490 !26869525     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26869525 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomol+Ther+(Seoul) 2016 ; 24 (2 ): 109-14 Nephropedia Template TP {{tp|p=26869525 |t=2016. iRhoms; Its Functions and Essential Roles |pdf=|usr=}}{{26869525 }} gab.com Text iRhoms; Its Functions and Essential Roles JO: Biomol Ther (Seoul) http://www.kidney.de/pget.php?&tw=1&pmid=26869525 #FOAvip In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking essential catalytic residues. These are necessary for maturation and traffickingof tumor necrosis factor-alpha (TNF-?) converting enzyme (TACE) from endoplasmic reticulum (ER) to plasma membrane through Golgi, and associated with the fates of various ligands for EGFR. Recent studies have clarifiedthat the activation or downregulation of EGFR signaling pathways by alteration of iRhoms are connected to several human diseases including tylosis with esophageal cancer (TOC) which is the autosomal dominant syndrom, breast cancer, and Alzheimer's disease. Thus, this review focuses on our understanding of iRhoms and the involved mechanisms in the cellular processes. Twit Text FOAVip iRhoms; Its Functions and Essential Roles ????Biomol Ther (Seoul) http://www.kidney.de/pget.php?&tw=1&pmid=26869525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26869525 #FOAvip English Wikipedia <ref>{{Cite pmid|26869525 }}</ref> iRhoms; Its Functions and Essential Roles #MMPMID26869525 Lee MY ; Nam KH ; Choi KC Biomol Ther (Seoul) 2016[Mar]; 24 (2 ): 109-14 PMID26869525 show ga In Drosophila, rhomboid proteases are active cardinal regulators of epidermal growth factor receptor (EGFR) signaling pathway. iRhom1 and iRhom2, which are inactive homologs of rhomboid intramembrane serine proteases, are lacking essential catalytic residues. These are necessary for maturation and traffickingof tumor necrosis factor-alpha (TNF-?) converting enzyme (TACE) from endoplasmic reticulum (ER) to plasma membrane through Golgi, and associated with the fates of various ligands for EGFR. Recent studies have clarifiedthat the activation or downregulation of EGFR signaling pathways by alteration of iRhoms are connected to several human diseases including tylosis with esophageal cancer (TOC) which is the autosomal dominant syndrom, breast cancer, and Alzheimer's disease. Thus, this review focuses on our understanding of iRhoms and the involved mechanisms in the cellular processes. äiRhoms; Its Functions and Essential Roles (epmc).pdf DeepDyve Pubget Overpricing