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2017 ; 8
(5
): 8900-8909
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?? T cells in cancer immunotherapy
#MMPMID27823972
Zou C
; Zhao P
; Xiao Z
; Han X
; Fu F
; Fu L
Oncotarget
2017[Jan]; 8
(5
): 8900-8909
PMID27823972
show ga
?? T cells are one of the three immune cell types that express antigen receptors.
They contribute to lymphoid antitumor surveillance and bridge the gap between
innate and adaptive immunity. ?? T cells have the capacity of secreting abundant
cytokines and exerting potent cytotoxicity against a wide range of cancer cells.
?? T cells exhibit important roles in immune-surveillance and immune defense
against tumors and have become attractive effector cells for cancer
immunotherapy. ?? T cells mediate anti-tumor therapy mainly by secreting
pro-apoptotic molecules and inflammatory cytokines, or through a TCR-dependent
pathway. Recently, ?? T cells are making their way into clinical trials. Some
clinical trials demonstrated that ?? T cell-based immunotherapy is well tolerated
and efficient. Despite the advantages that could be exploited, there are
obstacles have to be addressed for the development of ?? T cell immunotherapies.
Future direction for immunotherapy using ?? T cells should focus on overcoming
the side effects of ?? T cells and exploring better antigens that help
stimulating ?? T cell expansion in vitro.
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