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2014 ; 35
(12
): 613-621
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?? T cell surveillance via CD1 molecules
#MMPMID25283967
Luoma AM
; Castro CD
; Adams EJ
Trends Immunol
2014[Dec]; 35
(12
): 613-621
PMID25283967
show ga
?? T cells are a prominent epithelial-resident lymphocyte population, possessing
multi-functional capacities in the repair of host tissue, pathogen clearance, and
tumor surveillance. Although three decades have now passed since their discovery,
the nature of ?? T cell receptor (TCR)-mediated ligand recognition remains poorly
defined. Recent studies have provided structural insight into this recognition,
demonstrating that ?? T cells survey both CD1 and the presented lipid, and in
some cases are exquisitely lipid specific. We review these findings here,
examining the molecular basis for and the functional relevance of this
interaction. We discuss potential implications on the notion that non-classical
major histocompatibility complex (MHC) molecules may function as important
restricting elements of ?? TCR specificity, and on our understanding of ?? T cell
activation and function.