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?? T cell surveillance via CD1 molecules #MMPMID25283967
Luoma AM; Castro CD; Adams EJ
Trends Immunol 2014[Dec]; 35 (12): 613-21 PMID25283967show ga
?? T cells are a prominent epithelial-resident lymphocyte population, possessing multi-functional capacities in the repair of host tissue, pathogen clearance, and tumor surveillance. Although three decades have now passed since their discovery, the nature of ?? TCR-mediated ligand recognition remains poorly defined. Recent studies have provided structural insight into this recognition, demonstrating that ?? T cells survey both CD1 and the presented lipid, and in some cases are exquisitely lipid specific. We review these findings here, examining the molecular basis for and the functional relevance of this interaction. We discuss potential implications on the notion that non-classical MHC molecules may function as important restricting elements of ?? TCR specificity, and on our understanding of ?? T cell activation and function.