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2016 ; 22
(16
): 5458-66
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?-AApeptides as a New Class of Peptidomimetics
#MMPMID26945679
Teng P
; Shi Y
; Sang P
; Cai J
Chemistry
2016[Apr]; 22
(16
): 5458-66
PMID26945679
show ga
Sequence-specific peptidomimetics are molecules that mimic the structure and
function of peptides and proteins. With new backbones and molecular frameworks,
peptidomimetics are of considerable interest in addressing challenges encountered
in chemical biology and biomedical sciences. Based on the ?-PNA backbone, a new
class of peptidomimetics - "?-AApeptides" were recently developed. Both linear
and cyclic ?-AApeptides can be synthesized with high efficiency. Compared with
?-peptides, ?-AApeptides are resistant to enzymatic degradation, and amendable to
diversification with a variety of chemical groups. Moreover, they could mimic
primary and secondary structure, as well as the function of peptides, and show
promise in biological applications, such as the development of new agents
combating bacteria, cancer, and Alzheimer's disease. A few research outcomes of
?-AApeptides are highlighted in this Concept article, and a future perspective is
also proposed.
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