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cAMP signaling in subcellular compartments
#MMPMID24704321
Lefkimmiatis K
; Zaccolo M
Pharmacol Ther
2014[Sep]; 143
(3
): 295-304
PMID24704321
show ga
In the complex microcosm of a cell, information security and its faithful
transmission are critical for maintaining internal stability. To achieve a
coordinated response of all its parts to any stimulus the cell must protect the
information received from potentially confounding signals. Physical segregation
of the information transmission chain ensures that only the entities able to
perform the encoded task have access to the relevant information. The cAMP
intracellular signaling pathway is an important system for signal transmission
responsible for the ancestral 'flight or fight' response and involved in the
control of critical functions including frequency and strength of heart
contraction, energy metabolism and gene transcription. It is becoming
increasingly apparent that the cAMP signaling pathway uses compartmentalization
as a strategy for coordinating the large number of key cellular functions under
its control. Spatial confinement allows the formation of cAMP signaling "hot
spots" at discrete subcellular domains in response to specific stimuli, bringing
the information in proximity to the relevant effectors and their recipients, thus
achieving specificity of action. In this report we discuss how the different
constituents of the cAMP pathway are targeted and participate in the formation of
cAMP compartmentalized signaling events. We illustrate a few examples of
localized cAMP signaling, with a particular focus on the nucleus, the
sarcoplasmic reticulum and the mitochondria. Finally, we discuss the therapeutic
potential of interventions designed to perturb specific cAMP cascades locally.
|Animals
[MESH]
|Cellular Structures/*metabolism
[MESH]
|Cyclic AMP-Dependent Protein Kinases/metabolism
[MESH]
free
free
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