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10.18632/oncotarget.12701 http://scihub22266oqcxt.onion/10.18632/oncotarget.12701 C5347691!5347691 !27756891     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27756891 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27756891 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (50 ): 82273-82288 Nephropedia Template TP {{tp|p=27756891 |t=2016. c-Myc deregulation induces mRNA capping enzyme dependency |pdf=|usr=}}{{27756891 }} gab.com Text c-Myc deregulation induces mRNA capping enzyme dependency JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27756891 #FOAvip c-Myc is a potent driver of many human cancers. Since strategies for directly targeting c-Myc protein have had limited success, upstream regulators and downstream effectors of c-Myc are being investigated as alternatives for therapeutic intervention. c-Myc regulates transcription and formation of the mRNA cap, which is important for transcript maturation and translation. However, the direct mechanism by which c-Myc upregulates mRNA capping is unclear. mRNA cap formation initiates with the linkage of inverted guanosine via a triphosphate bridge to the first transcribed nucleotide, catalysed by mRNA capping enzyme (CE/RNGTT). Here we report that c-Myc increases the recruitment of catalytically active CE to RNA polymerase II and to its target genes. c-Myc-induced target gene expression, cell proliferation and cell transformation is highly dependent on CE, but only when c-Myc is deregulated. Cells retaining normal control of c-Myc expression are insensitive to repression of CE. c-Myc expression is also dependent on CE. Therefore, inhibiting CE provides an attractive route for selective therapeutic targeting of cancer cells which have acquired deregulated c-Myc. Twit Text FOAVip c-Myc deregulation induces mRNA capping enzyme dependency ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27756891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27756891 #FOAvip English Wikipedia <ref>{{Cite pmid|27756891 }}</ref> c-Myc deregulation induces mRNA capping enzyme dependency #MMPMID27756891 Lombardi O ; Varshney D ; Phillips NM ; Cowling VH Oncotarget 2016[Dec]; 7 (50 ): 82273-82288 PMID27756891 show ga c-Myc is a potent driver of many human cancers. Since strategies for directly targeting c-Myc protein have had limited success, upstream regulators and downstream effectors of c-Myc are being investigated as alternatives for therapeutic intervention. c-Myc regulates transcription and formation of the mRNA cap, which is important for transcript maturation and translation. However, the direct mechanism by which c-Myc upregulates mRNA capping is unclear. mRNA cap formation initiates with the linkage of inverted guanosine via a triphosphate bridge to the first transcribed nucleotide, catalysed by mRNA capping enzyme (CE/RNGTT). Here we report that c-Myc increases the recruitment of catalytically active CE to RNA polymerase II and to its target genes. c-Myc-induced target gene expression, cell proliferation and cell transformation is highly dependent on CE, but only when c-Myc is deregulated. Cells retaining normal control of c-Myc expression are insensitive to repression of CE. c-Myc expression is also dependent on CE. Therefore, inhibiting CE provides an attractive route for selective therapeutic targeting of cancer cells which have acquired deregulated c-Myc. |Binding Sites [MESH] |Cell Proliferation [MESH] |Cell Transformation, Neoplastic/genetics/metabolism/pathology [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |HeLa Cells [MESH] |Humans [MESH] |Mammary Glands, Human/*enzymology [MESH] |Nucleotidyltransferases/genetics/*metabolism [MESH] |Promoter Regions, Genetic [MESH] |Protein Binding [MESH] |Proto-Oncogene Proteins c-myc/genetics/*metabolism [MESH] |RNA Caps/genetics/*metabolism [MESH] |RNA Interference [MESH] |RNA Polymerase II/metabolism [MESH] |RNA, Messenger/genetics/*metabolism [MESH] |Transfection [MESH] |Uterine Cervical Neoplasms/*enzymology/genetics/pathology [MESH]c-Myc deregulation induces mRNA capping enzyme dependency (epmc).pdf DeepDyve Pubget Overpricing