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10.1371/journal.pone.0133280 http://scihub22266oqcxt.onion/10.1371/journal.pone.0133280 C4514710!4514710 !26208222     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26208222 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       PLoS+One 2015 ; 10 (7 ): e0133280 Nephropedia Template TP {{tp|p=26208222 |t=2015. c-Myb Binding Sites in Haematopoietic Chromatin Landscapes |pdf=|usr=}}{{26208222 }} gab.com Text c-Myb Binding Sites in Haematopoietic Chromatin Landscapes JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26208222 #FOAvip Strict control of tissue-specific gene expression plays a pivotal role during lineage commitment. The transcription factor c-Myb has an essential role in adult haematopoiesis and functions as an oncogene when rearranged in human cancers. Here we have exploited digital genomic footprinting analysis to obtain a global picture of c-Myb occupancy in the genome of six different haematopoietic cell-types. We have biologically validated several c-Myb footprints using c-Myb knockdown data, reporter assays and DamID analysis. We show that our predicted conserved c-Myb footprints are highly dependent on the haematopoietic cell type, but that there is a group of gene targets common to all cell-types analysed. Furthermore, we find that c-Myb footprints co-localise with active histone mark H3K4me3 and are significantly enriched at exons. We analysed co-localisation of c-Myb footprints with 104 chromatin regulatory factors in K562 cells, and identified nine proteins that are enriched together with c-Myb footprints on genes positively regulated by c-Myb and one protein enriched on negatively regulated genes. Our data suggest that c-Myb is a transcription factor with multifaceted target regulation depending on cell type. Twit Text FOAVip c-Myb Binding Sites in Haematopoietic Chromatin Landscapes ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26208222 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26208222 #FOAvip English Wikipedia <ref>{{Cite pmid|26208222 }}</ref> c-Myb Binding Sites in Haematopoietic Chromatin Landscapes #MMPMID26208222 Bengtsen M ; Klepper K ; Gundersen S ; Cuervo I ; Drabløs F ; Hovig E ; Sandve GK ; Gabrielsen OS ; Eskeland R PLoS One 2015[]; 10 (7 ): e0133280 PMID26208222 show ga Strict control of tissue-specific gene expression plays a pivotal role during lineage commitment. The transcription factor c-Myb has an essential role in adult haematopoiesis and functions as an oncogene when rearranged in human cancers. Here we have exploited digital genomic footprinting analysis to obtain a global picture of c-Myb occupancy in the genome of six different haematopoietic cell-types. We have biologically validated several c-Myb footprints using c-Myb knockdown data, reporter assays and DamID analysis. We show that our predicted conserved c-Myb footprints are highly dependent on the haematopoietic cell type, but that there is a group of gene targets common to all cell-types analysed. Furthermore, we find that c-Myb footprints co-localise with active histone mark H3K4me3 and are significantly enriched at exons. We analysed co-localisation of c-Myb footprints with 104 chromatin regulatory factors in K562 cells, and identified nine proteins that are enriched together with c-Myb footprints on genes positively regulated by c-Myb and one protein enriched on negatively regulated genes. Our data suggest that c-Myb is a transcription factor with multifaceted target regulation depending on cell type. |*Binding Sites [MESH] |Cell Differentiation/genetics [MESH] |Chromatin/*genetics/*metabolism [MESH] |DNA Footprinting [MESH] |Gene Expression Regulation [MESH] |Genome-Wide Association Study [MESH] |Hematopoiesis/*genetics [MESH] |Histones/metabolism [MESH] |Humans [MESH] |K562 Cells [MESH] |Protein Binding [MESH] |Proto-Oncogene Proteins c-myb/*metabolism [MESH] |Transcription Factors/metabolism [MESH]c-Myb Binding Sites in Haematopoietic Chromatin Landscapes (epmc).pdf DeepDyve Pubget Overpricing