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?3-adrenoreceptor and tumor microenvironment: a new hub
#MMPMID26504670
Chiarugi P
; Filippi L
Oncoimmunology
2015[Nov]; 4
(11
): e1026532
PMID26504670
show ga
The achievement of malignant traits in several cancers is associated with tumor
microenvironment reactivity. New evidence show that the stress hormone
noradrenaline enhances melanoma microenvironment reactivity, mainly acting
through ?3-adrenoreceptors (?(2)-ARs), favoring recruitment of cancer-associated
fibroblasts, M2-macrophages, bone marrow-derived precursors, These events concur
in sustaining a pro-inflammatory and pro-angiogenic milieu, finally boosting
melanoma malignancy.