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2016 ; 365
(3
): 511-9
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?v integrins: key regulators of tissue fibrosis
#MMPMID27139180
Conroy KP
; Kitto LJ
; Henderson NC
Cell Tissue Res
2016[Sep]; 365
(3
): 511-9
PMID27139180
show ga
Chronic tissue injury with fibrosis results in the disruption of tissue
architecture, organ dysfunction and eventual organ failure. Therefore, the
development of effective anti-fibrotic therapies is urgently required. During
fibrogenesis, complex interplay occurs between cellular and extracellular matrix
components of the wound healing response. Integrins, a family of transmembrane
cell adhesion molecules, play a key role in mediating intercellular and
cell-matrix interactions. Thus, integrins provide a major node of communication
between the extracellular matrix, inflammatory cells, fibroblasts and parenchymal
cells and, as such, are intimately involved in the initiation, maintenance and
resolution of tissue fibrosis. Modulation of members of the ?v integrin family
has exhibited profound effects on fibrosis in multiple organs and disease states.
In this review, we discuss the current knowledge of the mechanisms of
?v-integrin-mediated regulation of fibrogenesis and show that the therapeutic
targeting of specific ?v integrins represents a promising avenue to treat
patients with a broad range of fibrotic diseases.
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