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10.1097/01.mnh.0000447024.97464.a3 http://scihub22266oqcxt.onion/10.1097/01.mnh.0000447024.97464.a3 C4141856!4141856 !24867676     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24867676 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Nephrol+Hypertens 2014 ; 23 (4 ): 331-9 Nephropedia Template TP {{tp|p=24867676 |t=2014. ?Klotho and vascular calcification: an evolving paradigm |pdf=|usr=}}{{24867676 }} gab.com Text Klotho and vascular calcification: an evolving paradigm JO: Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=24867676 #FOAvip PURPOSE OF REVIEW: Cardiovascular disease remains the single most serious contributor to mortality in chronic kidney disease (CKD). Although conventional risk factors are prevalent in CKD, both cardiomyopathy and vasculopathy can be caused by pathophysiologic mechanisms specific to the uremic state. CKD is a state of systemic ?Klotho deficiency. Although the molecular mechanism of action of ?Klotho is not well understood, the downstream targets and biologic functions of ?Klotho are astonishingly pleiotropic. An emerging body of literature links ?Klotho to uremic vasculopathy. RECENT FINDINGS: The expression of ?Klotho in the vasculature is controversial because of conflicting data. Regardless of whether ?Klotho acts as a circulating or resident protein, there are good data associating changes in ?Klotho levels with vascular pathology including vascular calcification and in-vitro data of the direct action of ?Klotho on both the endothelium and vascular smooth muscle cells in terms of cytoprotection and prevention of mineralization. SUMMARY: It is critical to understand the pathogenic role of ?Klotho on the integral endothelium-vascular smooth muscle network rather than each cell type in isolation in uremic vasculopathy, as ?Klotho can serve as a potential prognostic biomarker and a biological therapeutic agent. Twit Text FOAVip Klotho and vascular calcification: an evolving paradigm ????Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=24867676 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24867676 #FOAvip English Wikipedia <ref>{{Cite pmid|24867676 }}</ref> ?Klotho and vascular calcification: an evolving paradigm #MMPMID24867676 Hu MC ; Kuro-o M ; Moe OW Curr Opin Nephrol Hypertens 2014[Jul]; 23 (4 ): 331-9 PMID24867676 show ga PURPOSE OF REVIEW: Cardiovascular disease remains the single most serious contributor to mortality in chronic kidney disease (CKD). Although conventional risk factors are prevalent in CKD, both cardiomyopathy and vasculopathy can be caused by pathophysiologic mechanisms specific to the uremic state. CKD is a state of systemic ?Klotho deficiency. Although the molecular mechanism of action of ?Klotho is not well understood, the downstream targets and biologic functions of ?Klotho are astonishingly pleiotropic. An emerging body of literature links ?Klotho to uremic vasculopathy. RECENT FINDINGS: The expression of ?Klotho in the vasculature is controversial because of conflicting data. Regardless of whether ?Klotho acts as a circulating or resident protein, there are good data associating changes in ?Klotho levels with vascular pathology including vascular calcification and in-vitro data of the direct action of ?Klotho on both the endothelium and vascular smooth muscle cells in terms of cytoprotection and prevention of mineralization. SUMMARY: It is critical to understand the pathogenic role of ?Klotho on the integral endothelium-vascular smooth muscle network rather than each cell type in isolation in uremic vasculopathy, as ?Klotho can serve as a potential prognostic biomarker and a biological therapeutic agent. |Animals [MESH] |Endothelium/*physiopathology [MESH] |Glucuronidase/*blood/deficiency [MESH] |Humans [MESH] |Klotho Proteins [MESH] |Muscle, Smooth, Vascular/*physiopathology [MESH] |Renal Insufficiency, Chronic/*blood [MESH] |Uremia/blood [MESH] |Vascular Calcification/*blood [MESH]?Klotho and vascular calcification: an evolving paradigm (epmc).pdf DeepDyve Pubget Overpricing