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10.1111/jth.12915 http://scihub22266oqcxt.onion/10.1111/jth.12915 C4888797!4888797 !26149019     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26149019 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Thromb+Haemost 2015 ; 13 Suppl 1 (Suppl 1 ): S17-25 Nephropedia Template TP {{tp|p=26149019 |t=2015. ?IIb?3: structure and function |pdf=|usr=}}{{26149019 }} gab.com Text IIb 3: structure and function JO: J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=26149019 #FOAvip During the past decade, advanced techniques in structural biology have provided atomic level information on the platelet integrin ?IIb?3 activation mechanism that results in it adopting a high-affinity ligand-binding conformation(s). This review focuses on advances in imaging intact ?IIb?3 in a lipid bilayer in the absence of detergent and new structural insights into the changes in the ligand-binding pocket with receptor activation and ligand binding. It concludes with descriptions of novel therapeutic ?IIb?3 antagonists being developed based on an advanced knowledge of the receptor's structure. Twit Text FOAVip IIb 3: structure and function ????J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=26149019 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26149019 #FOAvip English Wikipedia <ref>{{Cite pmid|26149019 }}</ref> ?IIb?3: structure and function #MMPMID26149019 Coller BS J Thromb Haemost 2015[Jun]; 13 Suppl 1 (Suppl 1 ): S17-25 PMID26149019 show ga During the past decade, advanced techniques in structural biology have provided atomic level information on the platelet integrin ?IIb?3 activation mechanism that results in it adopting a high-affinity ligand-binding conformation(s). This review focuses on advances in imaging intact ?IIb?3 in a lipid bilayer in the absence of detergent and new structural insights into the changes in the ligand-binding pocket with receptor activation and ligand binding. It concludes with descriptions of novel therapeutic ?IIb?3 antagonists being developed based on an advanced knowledge of the receptor's structure. |*Hemostasis/drug effects [MESH] |Animals [MESH] |Binding Sites [MESH] |Blood Platelets/drug effects/*metabolism [MESH] |Drug Design [MESH] |Humans [MESH] |Ligands [MESH] |Models, Molecular [MESH] |Platelet Aggregation Inhibitors/therapeutic use [MESH] |Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors/chemistry/*metabolism [MESH] |Protein Binding [MESH] |Protein Conformation [MESH] |Signal Transduction [MESH]?IIb?3: structure and function (epmc).pdf DeepDyve Pubget Overpricing