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10.1093/bioinformatics/btv469 http://scihub22266oqcxt.onion/10.1093/bioinformatics/btv469 C4653393!4653393 !26283699     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26283699 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Bioinformatics 2015 ; 31 (23 ): 3859-61 Nephropedia Template TP {{tp|p=26283699 |t=2015. aRrayLasso: a network-based approach to microarray interconversion |pdf=|usr=}}{{26283699 }} gab.com Text aRrayLasso: a network-based approach to microarray interconversion JO: Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=26283699 #FOAvip Robust conversion between microarray platforms is needed to leverage the wide variety of microarray expression studies that have been conducted to date. Currently available conversion methods rely on manufacturer annotations, which are often incomplete, or on direct alignment of probes from different platforms, which often fail to yield acceptable genewise correlation. Here, we describe aRrayLasso, which uses the Lasso-penalized generalized linear model to model the relationships between individual probes in different probe sets. We have implemented aRrayLasso in a set of five open-source R functions that allow the user to acquire data from public sources such as Gene Expression Omnibus, train a set of Lasso models on that data and directly map one microarray platform to another. aRrayLasso significantly predicts expression levels with similar fidelity to technical replicates of the same RNA pool, demonstrating its utility in the integration of datasets from different platforms. AVAILABILITY AND IMPLEMENTATION: All functions are available, along with descriptions, at https://github.com/adam-sam-brown/aRrayLasso. CONTACT: chirag_patel@hms.harvard.edu. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. Twit Text FOAVip aRrayLasso: a network-based approach to microarray interconversion ????Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=26283699 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26283699 #FOAvip English Wikipedia <ref>{{Cite pmid|26283699 }}</ref> aRrayLasso: a network-based approach to microarray interconversion #MMPMID26283699 Brown AS ; Patel CJ Bioinformatics 2015[Dec]; 31 (23 ): 3859-61 PMID26283699 show ga Robust conversion between microarray platforms is needed to leverage the wide variety of microarray expression studies that have been conducted to date. Currently available conversion methods rely on manufacturer annotations, which are often incomplete, or on direct alignment of probes from different platforms, which often fail to yield acceptable genewise correlation. Here, we describe aRrayLasso, which uses the Lasso-penalized generalized linear model to model the relationships between individual probes in different probe sets. We have implemented aRrayLasso in a set of five open-source R functions that allow the user to acquire data from public sources such as Gene Expression Omnibus, train a set of Lasso models on that data and directly map one microarray platform to another. aRrayLasso significantly predicts expression levels with similar fidelity to technical replicates of the same RNA pool, demonstrating its utility in the integration of datasets from different platforms. AVAILABILITY AND IMPLEMENTATION: All functions are available, along with descriptions, at https://github.com/adam-sam-brown/aRrayLasso. CONTACT: chirag_patel@hms.harvard.edu. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online. |Gene Expression Profiling/*methods [MESH] |Linear Models [MESH] |Oligonucleotide Array Sequence Analysis/*methods [MESH]aRrayLasso: a network-based approach to microarray interconversion (epmc).pdf DeepDyve Pubget Overpricing