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2016 ; 31
(ä): 120-5
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Zn(2+) at a cellular crossroads
#MMPMID27010344
Liang X
; Dempski RE
; Burdette SC
Curr Opin Chem Biol
2016[Apr]; 31
(ä): 120-5
PMID27010344
show ga
Zinc is an essential micronutrient for cellular homeostasis. Initially proposed
to only contribute to cellular viability through structural roles and non-redox
catalysis, advances in quantifying changes in nM and pM quantities of Zn(2+) have
elucidated increasing functions as an important signaling molecule. This includes
Zn(2+)-mediated regulation of transcription factors and subsequent protein
expression, storage and release of intracellular compartments of zinc quanta into
the extracellular space which modulates plasma membrane protein function, as well
as intracellular signaling pathways which contribute to the immune response. This
review highlights some recent advances in our understanding of zinc signaling.