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2017 ; 3
(ä): 17071
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Zinc-finger proteins in health and disease
#MMPMID29152378
Cassandri M
; Smirnov A
; Novelli F
; Pitolli C
; Agostini M
; Malewicz M
; Melino G
; Raschellà G
Cell Death Discov
2017[]; 3
(ä): 17071
PMID29152378
show ga
Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and
have a wide range of molecular functions. Given the wide variety of zinc-finger
domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other
proteins. Thus, ZNFs are involved in the regulation of several cellular
processes. In fact, ZNFs are implicated in transcriptional regulation,
ubiquitin-mediated protein degradation, signal transduction, actin targeting, DNA
repair, cell migration, and numerous other processes. The aim of this review is
to provide a comprehensive summary of the current state of knowledge of this
class of proteins. Firstly, we describe the actual classification of ZNFs, their
structure and functions. Secondly, we focus on the biological role of ZNFs in the
development of organisms under normal physiological and pathological conditions.