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2017 ; 3
(2
): e1602899
Nephropedia Template TP
Uraki R
; Hwang J
; Jurado KA
; Householder S
; Yockey LJ
; Hastings AK
; Homer RJ
; Iwasaki A
; Fikrig E
Sci Adv
2017[Feb]; 3
(2
): e1602899
PMID28261663
show ga
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that has recently been
found to cause fetal infection and neonatal abnormalities, including microcephaly
and neurological dysfunction. ZIKV persists in the semen months after the acute
viremic phase in humans. To further understand the consequences of ZIKV
persistence in males, we infected Ifnar1(-/-) mice via subcutaneous injection of
a pathogenic but nonlethal ZIKV strain. ZIKV replication persists within the
testes even after clearance from the blood, with interstitial,
testosterone-producing Leydig cells supporting virus replication. We found high
levels of viral RNA and antigen within the epididymal lumen, where sperm is
stored, and within surrounding epithelial cells. Unexpectedly, at 21 days
post-infection, the testes of the ZIKV-infected mice were significantly smaller
compared to those of mock-infected mice, indicating progressive testicular
atrophy. ZIKV infection caused a reduction in serum testosterone, suggesting that
male fertility can be affected. Our findings have important implications for
nonvector-borne vertical transmission, as well as long-term potential
reproductive deficiencies, in ZIKV-infected males.
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