Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27029595
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Microbiol+Rev
2016 ; 29
(3
): 487-524
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Zika Virus
#MMPMID27029595
Musso D
; Gubler DJ
Clin Microbiol Rev
2016[Jul]; 29
(3
): 487-524
PMID27029595
show ga
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus
and the family Flaviviridae. ZIKV was first isolated from a nonhuman primate in
1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were
sporadic for half a century before emerging in the Pacific and the Americas. ZIKV
is usually transmitted by the bite of infected mosquitoes. The clinical
presentation of Zika fever is nonspecific and can be misdiagnosed as other
infectious diseases, especially those due to arboviruses such as dengue and
chikungunya. ZIKV infection was associated with only mild illness prior to the
large French Polynesian outbreak in 2013 and 2014, when severe neurological
complications were reported, and the emergence in Brazil of a dramatic increase
in severe congenital malformations (microcephaly) suspected to be associated with
ZIKV. Laboratory diagnosis of Zika fever relies on virus isolation or detection
of ZIKV-specific RNA. Serological diagnosis is complicated by cross-reactivity
among members of the Flavivirus genus. The adaptation of ZIKV to an urban cycle
involving humans and domestic mosquito vectors in tropical areas where dengue is
endemic suggests that the incidence of ZIKV infections may be underestimated.
There is a high potential for ZIKV emergence in urban centers in the tropics that
are infested with competent mosquito vectors such as Aedes aegypti and Aedes
albopictus.
free
free
free
