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2015 ; 3
(2
): 163-170
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Zebrafish Models of Kidney Damage and Repair
#MMPMID28690924
Cirio MC
; de Caestecker MP
; Hukriede NA
Curr Pathobiol Rep
2015[Jun]; 3
(2
): 163-170
PMID28690924
show ga
The vertebrate kidney possesses the capacity to repair damaged nephrons, and this
potential is conserved regardless of the complexity of species-specific kidneys.
However, many aquatic vertebrates possess the ability to not only repair existing
nephrons, but also generate new nephrons after injury. Adult zebrafish have the
ability to recover from acute renal injury not only by replacing lost injured
epithelial cells of endogenous nephrons, but by also generating de novo nephrons.
This strong regeneration potential, along with other unique characteristics such
as the high degree of genetic conservation with humans, the ease of harvesting
externally fertilized, transparent embryos, the accessibility to larval and adult
kidneys, and the ability to perform whole organism phenotypic small molecule
screens, has positioned zebrafish as a unique vertebrate model to study kidney
injury. In this review, we provide an overview of the contribution of zebrafish
larvae/adult studies to the understanding of renal regeneration, diseases, and
therapeutic discovery.