Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/srep16229 http://scihub22266oqcxt.onion/10.1038/srep16229 C4635361!4635361 !26542173     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26542173 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 16229 Nephropedia Template TP {{tp|p=26542173 |t=2015. ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6 |pdf=|usr=}}{{26542173 }} gab.com Text ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26542173 #FOAvip RNA binding proteins (RBPs)-mediated post-transcriptional control has been implicated in influencing various aspects of RNA metabolism and playing important roles in mammalian development and pathological diseases. However, the functions of specific RBPs and the molecular mechanisms through which they act in monocyte/macrophage differentiation remain to be determined. In this study, through bioinformatics analysis and experimental validation, we identify that ZFP36L1, a member of ZFP36 zinc finger protein family, exhibits significant decrease in acute myeloid leukemia (AML) patients compared with normal controls and remarkable time-course increase during monocyte/macrophage differentiation of PMA-induced THP-1 and HL-60 cells as well as induction culture of CD34(+) hematopoietic stem/progenitor cells (HSPCs). Lentivirus-mediated gain and loss of function assays demonstrate that ZFP36L1 acts as a positive regulator to participate in monocyte/macrophage differentiation. Mechanistic investigation further reveals that ZFP36L1 binds to the CDK6 mRNA 3'untranslated region bearing adenine-uridine rich elements and negatively regulates the expression of CDK6 which is subsequently demonstrated to impede the in vitro monocyte/macrophage differentiation of CD34(+) HSPCs. Collectively, our work unravels a ZFP36L1-mediated regulatory circuit through repressing CDK6 expression during monocyte/macrophage differentiation, which may also provide a therapeutic target for AML therapy. Twit Text FOAVip ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26542173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26542173 #FOAvip English Wikipedia <ref>{{Cite pmid|26542173 }}</ref> ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6 #MMPMID26542173 Chen MT ; Dong L ; Zhang XH ; Yin XL ; Ning HM ; Shen C ; Su R ; Li F ; Song L ; Ma YN ; Wang F ; Zhao HL ; Yu J ; Zhang JW Sci Rep 2015[Nov]; 5 (ä): 16229 PMID26542173 show ga RNA binding proteins (RBPs)-mediated post-transcriptional control has been implicated in influencing various aspects of RNA metabolism and playing important roles in mammalian development and pathological diseases. However, the functions of specific RBPs and the molecular mechanisms through which they act in monocyte/macrophage differentiation remain to be determined. In this study, through bioinformatics analysis and experimental validation, we identify that ZFP36L1, a member of ZFP36 zinc finger protein family, exhibits significant decrease in acute myeloid leukemia (AML) patients compared with normal controls and remarkable time-course increase during monocyte/macrophage differentiation of PMA-induced THP-1 and HL-60 cells as well as induction culture of CD34(+) hematopoietic stem/progenitor cells (HSPCs). Lentivirus-mediated gain and loss of function assays demonstrate that ZFP36L1 acts as a positive regulator to participate in monocyte/macrophage differentiation. Mechanistic investigation further reveals that ZFP36L1 binds to the CDK6 mRNA 3'untranslated region bearing adenine-uridine rich elements and negatively regulates the expression of CDK6 which is subsequently demonstrated to impede the in vitro monocyte/macrophage differentiation of CD34(+) HSPCs. Collectively, our work unravels a ZFP36L1-mediated regulatory circuit through repressing CDK6 expression during monocyte/macrophage differentiation, which may also provide a therapeutic target for AML therapy. |3' Untranslated Regions/genetics [MESH] |Antigens, CD34/metabolism [MESH] |Butyrate Response Factor 1/*metabolism [MESH] |Cell Differentiation/*physiology [MESH] |Cell Line [MESH] |Cell Line, Tumor [MESH] |Cyclin-Dependent Kinase 6/*metabolism [MESH] |HEK293 Cells [MESH] |HL-60 Cells [MESH] |Hematopoiesis/genetics/physiology [MESH] |Hematopoietic Stem Cells/metabolism [MESH] |Humans [MESH] |Macrophages/*metabolism [MESH] |Monocytes/*metabolism [MESH] |Nuclear Proteins/metabolism [MESH] |RNA, Messenger/genetics [MESH] |RNA, Small Interfering/genetics [MESH] |RNA-Binding Proteins/metabolism [MESH]ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK(epmc).pdf DeepDyve Pubget Overpricing